Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | GUSB | P08236 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10373335 | 0.87 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10373624 | 0.82 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10372929 | 0.81 | PDE3B (0.62) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10374221 | 0.81 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10373374 | 0.81 | PDE3B (0.68) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10375588 | 0.81 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9677178 | 0.81 | PDE3B (0.75) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Adibendan SCHEMBL9832050 | 0.80 | PDE3B (0.90) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10374060 | 0.79 | PDE3B (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Adibendan SCHEMBL10470994 | 0.79 | PDE3B (0.88) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318902-A2 | Use of linear annelated tricyclics as inhibitors of erythrocyte aggregation | Roche Diagnostics GmbH (DE) | 1989-06-07 | — | — | EP | claimed |