Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | TOP1 | P11387 | 5/20 | 0.46 |
| ▸ | TOP2A | P11388 | 6/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10373274 | 0.94 | ALDH1A1 (0.49) | ALDH1A1KDM4EPOLBHSP90AA1RXFP1 | |
| SCHEMBL10374513 | 0.94 | KDM4E (0.57) | ALDH1A1KDM4EPOLBHSP90AA1RXFP1 | |
| SCHEMBL10895910 | 0.88 | KDM4E (0.47) | ALDH1A1KDM4EPOLBHSP90AA1RXFP1 | |
| SCHEMBL10965287 | 0.88 | TOP2A (0.49) | ALDH1A1KDM4EPOLBHSP90AA1RXFP1 | |
| SCHEMBL10373776 | 0.86 | KDM4E (0.62) | ALDH1A1KDM4EPOLBHSP90AA1RXFP1 | |
| SCHEMBL9869412 | 0.85 | TOP2A (0.61) | ALDH1A1POLBKMT2ATOP1TOP2A | |
| Hydrochloric Acid SCHEMBL9869916 | 0.85 | TOP2A (0.60) | ALDH1A1POLBKMT2ATOP1TOP2A | |
| SCHEMBL10895749 | 0.83 | TOP1 (0.63) | ALDH1A1KDM4EPOLBHSP90AA1RXFP1 | |
| SCHEMBL9536179 | 0.83 | KMT2A (0.61) | ALDH1A1KDM4EPOLBLMNAMEN1 | |
| SCHEMBL10894425 | 0.83 | TOP1 (0.51) | ALDH1A1KDM4EPOLBHSP90AA1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154780-B1 | QUINOLINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-04-11 | — | — | EP | disclosed |