Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10376659 | 0.91 | KMT2A (0.51) | KMT2AKDM4EMAPK1POLBNPSR1 | |
| SCHEMBL10375355 | 0.88 | ALDH1A1 (0.53) | KMT2AKDM4EPOLBNPSR1MAPT | |
| SCHEMBL10375291 | 0.85 | KDM4E (0.59) | KDM4EMAPK1NPSR1MAPTAR | |
| SCHEMBL10375314 | 0.82 | ABCG2 (0.51) | KMT2AKDM4ENPSR1ABCG2ABCB1 | |
| SCHEMBL10377324 | 0.82 | KMT2A (0.48) | KMT2AKDM4ENPSR1MAPTABCG2 | |
| SCHEMBL10375337 | 0.81 | USP2 (0.50) | KMT2APOLBNPSR1MAPTALDH1A1 | |
| SCHEMBL10377355 | 0.80 | KDM4E (0.61) | KMT2AKDM4ENPSR1RAB9AALDH1A1 | |
| SCHEMBL10375340 | 0.80 | TMEM97 (0.48) | KMT2AKDM4EPOLBNPSR1MAPT | |
| SCHEMBL10375313 | 0.79 | KMT2A (0.49) | KMT2AMAPK1POLBNPSR1MAPT | |
| SCHEMBL10377358 | 0.79 | NPC1 (0.50) | KMT2APOLBMAPTABCG2ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169712-B1 | NEW PYRIMIDINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND COMPOSITION CONTAINING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-12-12 | — | — | EP | disclosed |
| US-4698340-A | TREATMENT OF CEREBROVASCULAR DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | disclosed |
| EP-0169712-A2 | New pyrimidine derivatives, processes for preparation thereof and composition containing the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-29 | — | — | EP | disclosed |