SCHEMBL10375439

SCHEMBL10375439

CC(=O)CC(=O)C=Cc1ccccc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.58
HDAC8 Q9BY41 1/20 0.58
HDAC6 Q9UBN7 1/20 0.58
GSR P00390 1/20 0.58
SMN1; SMN2 Q16637 6/20 0.56
HPGD P15428 3/20 0.56
LMNA P02545 3/20 0.56
RAB9A P51151 7/20 0.54
MAPT P10636 5/20 0.54
NPC1 O15118 4/20 0.54
MAOB P27338 3/20 0.54
BACE1 P56817 1/20 0.53
NFE2L2 Q16236 1/20 0.53
ALDH1A1 P00352 2/20 0.51
MEN1 O00255 5/20 0.50
KMT2A Q03164 5/20 0.50
HSP90AA1 P07900 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
MAOA P21397 1/20 0.50
TP53 P04637 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16198364 0.91 HDAC1 (0.68) HDAC1HDAC8HDAC6GSRSMN1; SMN2
SCHEMBL16198365 0.91 HDAC1 (0.68) HDAC1HDAC8HDAC6GSRSMN1; SMN2
SCHEMBL6955272 0.84 NFE2L2 (0.58) HDAC1HDAC8HDAC6GSRSMN1; SMN2
SCHEMBL27321841 0.83 SMN1; SMN2 (0.59) HDAC1HDAC8HDAC6GSRSMN1; SMN2
SCHEMBL11550275 0.81 NFE2L2 (0.54) LMNARAB9AMAPTBACE1NFE2L2
SCHEMBL11550267 0.81 NFE2L2 (0.54) LMNARAB9AMAPTBACE1NFE2L2
Hydrochloric Acid SCHEMBL27314775 0.81 SMN1; SMN2 (0.57) HDAC1HDAC8HDAC6GSRSMN1; SMN2
SCHEMBL1447675 0.80 MAPT (0.63) HDAC1HDAC8HDAC6GSRSMN1; SMN2
SCHEMBL1447672 0.80 MAPT (0.63) HDAC1HDAC8HDAC6GSRSMN1; SMN2
SCHEMBL31356685 0.80 MAPT (0.63) HDAC1HDAC8HDAC6GSRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0189045-B1 PYRIDOPYRIMIDINES, DIFFERENT PROCESSES FOR THEIR PREPARATION AS WELL AS THEIR USE AS MEDICAMENTS BAYER AG (DE) 1990-02-14 EP disclosed
US-4621082-A Pyridopyrimidines, pharmaceutical compositions and use BAYER AKTIENGESELLSCHAFT (DE) 1986-11-04 US disclosed
EP-0189045-A2 Pyridopyrimidines, different processes for their preparation as well as their use as medicaments BAYER AG (DE) 1986-07-30 EP disclosed