Perimetazine

Perimetazine

SCHEMBL1037545

COc1ccc2c(c1)N(CC(C)CN1CCC(O)CC1)c1ccccc1S2

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 4/20 0.62
CYP2D6 P10635 3/20 0.62
CHRM2 P08172 3/20 0.62
HTR1A P08908 3/20 0.62
ADRA2A P08913 3/20 0.62
CHRM1 P11229 3/20 0.62
DRD1 P21728 3/20 0.62
TBXA2R P21731 3/20 0.62
ADRA1A P35348 3/20 0.62
OPRM1 P35372 3/20 0.62
DRD3 P35462 3/20 0.62
KCNH2 Q12809 3/20 0.62
MAPK1 P28482 3/20 0.62
CYP1A2 P05177 2/20 0.62
LMNA P02545 2/20 0.62
CYP3A4 P08684 1/20 0.62
KDM1A O60341 1/20 0.54
SLC6A2 P23975 2/20 0.50
SLC6A4 P31645 2/20 0.50
SLC6A3 Q01959 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Perimetazine SCHEMBL29406905 1.00 PTGS1 (0.62) PTGS1CYP2D6CHRM2HTR1AADRA2A
SCHEMBL14540176 0.90 CYP2D6 (0.62) PTGS1CYP2D6CHRM2HTR1AADRA2A
SCHEMBL11686271 0.88 CYP2D6 (0.58) PTGS1CYP2D6CHRM2HTR1AADRA2A
SCHEMBL11686277 0.87 CYP2D6 (0.56) PTGS1CYP2D6CHRM2HTR1AADRA2A
SCHEMBL11686974 0.79 CYP2D6 (0.74) PTGS1CYP2D6CHRM2HTR1AADRA2A
SCHEMBL14340247 0.77 LMNA (0.46) PTGS1CYP2D6CHRM2HTR1AADRA2A
Dextromepromazine SCHEMBL23859840 0.77 CYP2D6 (1.00) PTGS1CYP2D6CHRM2HTR1AADRA2A
Levomepromazine SCHEMBL6944555 0.77 CYP2D6 (1.00) PTGS1CYP2D6CHRM2HTR1AADRA2A
Levomepromazine SCHEMBL25462 0.77 CYP2D6 (1.00) PTGS1CYP2D6CHRM2HTR1AADRA2A
Levomepromazine SCHEMBL8762418 0.77 CYP2D6 (1.00) PTGS1CYP2D6CHRM2HTR1AADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9757376-B2 Pharmaceutical compositions GM PHARMACEUTICALS, INC. (US) 2017-09-12 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
CN-1997400-A Conjugated psychotropic drugs and uses thereof UNIV RAMOT (IL) 2007-07-11 CN claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1727566-A2 CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF Ramot at Tel Aviv University Ltd. (IL) 2006-12-06 EP claimed
EP-1641446-A1 PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF Pediamed Pharmaceuticals, Inc. (US) 2006-04-05 EP claimed
WO-2005092392-A2 CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) 2005-10-06 WO claimed
WO-2004112771-A1 PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF PEDIAMED PHARMACEUTICALS, INC. (US) 2004-12-29 WO claimed
US-20040259809-A1 Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof PEDIAMED PHARMACEUTICALS, INC. 2004-12-23 US claimed
US-20040242570-A1 Conjugated psychotropic drugs and uses thereof BAR-ILAN UNIVERSITY (IL) 2004-12-02 US claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-10987365-B2 Compositions and methods for the treatment of pain GM PHARMACEUTICALS, INC. (US) 2021-04-27 US disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040242570-A1 Conjugated psychotropic drugs and uses thereof SLC18A2, SLC6A3, SLCO1B3 PTGS1 3095/4885CYP2D6 109/4885CHRM2 1673/4885
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 PTGS1 2981/4885CYP2D6 4855/4885CHRM2 4525/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.