Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | APAF1 | O14727 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375595 | 0.97 | SIGMAR1 (0.94) | SIGMAR1APAF1 | |
| Carvotroline SCHEMBL29710918 | 0.94 | SIGMAR1 (0.88) | SIGMAR1ACHE | |
| Carvotroline SCHEMBL350602 | 0.94 | SIGMAR1 (0.88) | SIGMAR1ACHE | |
| Carvotroline SCHEMBL123737 | 0.93 | SIGMAR1 (0.86) | SIGMAR1ACHE | |
| Gevotroline SCHEMBL293396 | 0.88 | SIGMAR1 (0.78) | SIGMAR1ACHE | |
| Gevotroline SCHEMBL30124880 | 0.88 | SIGMAR1 (0.78) | SIGMAR1ACHE | |
| Gevotroline SCHEMBL29710901 | 0.88 | SIGMAR1 (0.78) | SIGMAR1ACHE | |
| Gevotroline SCHEMBL120422 | 0.87 | SIGMAR1 (0.77) | SIGMAR1ACHEAPAF1 | |
| Gevotroline SCHEMBL4684544 | 0.87 | SIGMAR1 (0.77) | SIGMAR1ACHEAPAF1 | |
| Gevotroline SCHEMBL293397 | 0.87 | SIGMAR1 (0.77) | SIGMAR1ACHEAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223344-B1 | GAMMA-CARBOLINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-22 | — | — | EP | disclosed |
| EP-0223344-A1 | Gamma-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | disclosed |