Gevotroline

Gevotroline

SCHEMBL293396

Fc1ccc2[nH]c3c(c2c1)CN(CCCc1cccnc1)CC3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.78
ACHE P22303 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gevotroline SCHEMBL30124880 1.00 SIGMAR1 (0.78) SIGMAR1ACHE
Gevotroline SCHEMBL29710901 1.00 SIGMAR1 (0.78) SIGMAR1ACHE
Gevotroline SCHEMBL293397 0.99 SIGMAR1 (0.77) SIGMAR1ACHE
Gevotroline SCHEMBL31395347 0.99 SIGMAR1 (0.77) SIGMAR1ACHE
Gevotroline SCHEMBL120422 0.99 SIGMAR1 (0.77) SIGMAR1ACHE
Gevotroline SCHEMBL4684544 0.99 SIGMAR1 (0.77) SIGMAR1ACHE
SCHEMBL10375702 0.88 SIGMAR1 (1.00) SIGMAR1ACHE
SCHEMBL10375956 0.88 SIGMAR1 (0.63) SIGMAR1ACHE
SCHEMBL10375595 0.85 SIGMAR1 (0.94) SIGMAR1
SCHEMBL10127689 0.82 ACHE (0.67) SIGMAR1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS INC (US) 2025-09-25 US claimed
WO-2023212244-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS, INC. (US) 2023-11-02 WO claimed
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
US-20220146492-A1 CELL MEMBRANE PERMEABILITY RESTORING THERAPY SHINE IAN BASIL (US) 2022-05-12 US claimed
EP-3953000-A1 CELL MEMBRANE PERMEABILITY RESTORING THERAPY Shine, Ian Basil (US) 2022-02-16 EP claimed
WO-2020210643-A1 CELL MEMBRANE PERMEABILITY RESTORING THERAPY SHINE IAN BASIL (US) 2020-10-15 WO claimed
WO-2018015915-A1 A PARENTERAL CONTROLLED RELEASE COMPOSITION OF AN ATYPICAL ANTIPSYCHOTIC AGENT CADILA HEALTHCARE LIMITED (IN) 2018-01-25 WO claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
WO-2010014758-A1 USE OF HYDROGENATED PYRIDO[4,3-B] INDOLES FOR THE TREATMENT OF OXIDATIVE STRESS EDISON PHARMACEUTICALS, INC. (US) 2010-02-04 WO claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
EP-1931320-A2 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL GALENIC FORM COMPRISING SAME Flamel Technologies (FR) 2008-06-18 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
WO-2007036671-A2 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL GALENIC FORM COMPRISING SAME FLAMEL TECHNOLOGIES (FR) 2007-04-05 WO claimed
EP-1044023-B1 A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA LUITPOLD PHARM INC (US) 2005-05-25 EP claimed
EP-0223344-B1 GAMMA-CARBOLINES AMERICAN HOME PRODUCTS CORPORATION (US) 1990-08-22 EP claimed
EP-0223344-A1 Gamma-carbolines AMERICAN HOME PRODUCTS CORPORATION (US) 1987-05-27 EP claimed
US-4636563-A Antipsychotic γ-carbolines AMERICAN HOME PRODUCTS CORPORATION (US) 1987-01-13 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS HTR2A, HTR5A, HTR6 SIGMAR1 174/4885ACHE 273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.