Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377781 | 0.82 | HRH3 (0.43) | HRH3OPRM1KDM4EALDH1A1 | |
| SCHEMBL10376871 | 0.81 | GAA (0.48) | HRH3 | |
| SCHEMBL10375796 | 0.81 | HRH3 (0.41) | HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10858036 | 0.81 | HRH3 (0.43) | HRH3OPRM1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10858023 | 0.81 | HRH3 (0.43) | HRH3OPRM1KDM4EALDH1A1 | |
| SCHEMBL10375490 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1 | |
| SCHEMBL10761904 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1ALDH1A1 | |
| SCHEMBL10376883 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10375723 | 0.81 | HRH3 (0.43) | HRH3OPRM1KDM4EALDH1A1 | |
| SCHEMBL10375596 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187711-B1 | OCTAHYDROINDOLIZINE COMPOUNDS USEFUL AS ANALGESICS | McNeilab, Inc. (US) | 1990-08-29 | — | — | EP | claimed |
| EP-0187711-A2 | Octahydroindolizine compounds useful as analgesics | McNeilab, Inc. (US) | 1986-07-16 | — | — | EP | claimed |
| EP-0187711-B1 | OCTAHYDROINDOLIZINE COMPOUNDS USEFUL AS ANALGESICS | McNeilab, Inc. (US) | 1990-08-29 | — | — | EP | disclosed |
| CN-86100131-A | The preparation and the application thereof of octahydro indolizine compound | — | 1986-10-15 | — | — | CN | disclosed |
| EP-0187711-A2 | Octahydroindolizine compounds useful as analgesics | McNeilab, Inc. (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4582836-A | Octahydroindolizine compounds useful as analgesics | MCNEILAB, INC. (US) | 1986-04-15 | — | — | US | disclosed |