Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10538680 | 0.95 | OPRM1 (0.39) | HRH3OPRM1OPRK1 | |
| SCHEMBL10763691 | 0.94 | OPRM1 (0.43) | HRH3OPRM1OPRK1SIGMAR1 | |
| SCHEMBL9687389 | 0.89 | OPRM1 (0.42) | OPRM1OPRK1 | |
| SCHEMBL10921603 | 0.81 | ABCB1 (0.45) | HRH3OPRM1OPRK1ABCB1 | |
| SCHEMBL10376883 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1 | |
| SCHEMBL10375779 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1 | |
| SCHEMBL10761904 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1 | |
| SCHEMBL10375596 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10377530 | 0.79 | HRH3 (0.42) | HRH3OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL10375953 | 0.79 | HRH3 (0.42) | HRH3OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187711-B1 | OCTAHYDROINDOLIZINE COMPOUNDS USEFUL AS ANALGESICS | McNeilab, Inc. (US) | 1990-08-29 | — | — | EP | disclosed |
| EP-0187711-A2 | Octahydroindolizine compounds useful as analgesics | McNeilab, Inc. (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4582836-A | Octahydroindolizine compounds useful as analgesics | MCNEILAB, INC. (US) | 1986-04-15 | — | — | US | disclosed |