Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10376883 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1ALDH1A1 | |
| SCHEMBL10375779 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1KDM4EALDH1A1 | |
| SCHEMBL10761904 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1ALDH1A1 | |
| SCHEMBL10375490 | 0.81 | HRH3 (0.43) | HRH3OPRM1OPRK1SIGMAR1 | |
| SCHEMBL10921603 | 0.81 | ABCB1 (0.45) | HRH3OPRM1OPRK1KDM4EALDH1A1 | |
| SCHEMBL9688437 | 0.80 | HRH3 (0.43) | HRH3OPRM1OPRK1MAPT | |
| SCHEMBL10375698 | 0.80 | SIGMAR1 (0.49) | ALDH1A1HTR2CSIGMAR1 | |
| Hydrochloric Acid SCHEMBL10377530 | 0.79 | HRH3 (0.42) | HRH3OPRM1OPRK1ALDH1A1HTR2C | |
| Hydrochloric Acid SCHEMBL10375953 | 0.79 | HRH3 (0.42) | HRH3OPRM1OPRK1ALDH1A1HTR2C | |
| Hydrochloric Acid SCHEMBL10375951 | 0.79 | HRH3 (0.42) | HRH3OPRM1OPRK1ALDH1A1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187711-B1 | OCTAHYDROINDOLIZINE COMPOUNDS USEFUL AS ANALGESICS | McNeilab, Inc. (US) | 1990-08-29 | — | — | EP | claimed |
| EP-0187711-A2 | Octahydroindolizine compounds useful as analgesics | McNeilab, Inc. (US) | 1986-07-16 | — | — | EP | claimed |
| EP-0187711-B1 | OCTAHYDROINDOLIZINE COMPOUNDS USEFUL AS ANALGESICS | McNeilab, Inc. (US) | 1990-08-29 | — | — | EP | disclosed |
| CN-86100131-A | The preparation and the application thereof of octahydro indolizine compound | — | 1986-10-15 | — | — | CN | disclosed |
| EP-0187711-A2 | Octahydroindolizine compounds useful as analgesics | McNeilab, Inc. (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4582836-A | Octahydroindolizine compounds useful as analgesics | MCNEILAB, INC. (US) | 1986-04-15 | — | — | US | disclosed |