Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9695979 | 0.81 | ALDH1A1 (0.50) | PKMMAPTALDH1A1KMT2AIKBKB | |
| SCHEMBL31249024 | 0.73 | KDM4E (0.61) | PKMALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL839645 | 0.73 | KDM4E (0.61) | PKMALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1519692 | 0.73 | ALDH1A1 (0.69) | ALDH1A1HSP90AA1KMT2AHSD11B1SMN1; SMN2 | |
| SCHEMBL832452 | 0.73 | MAPT (0.54) | PKMMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL830827 | 0.73 | ALDH1A1 (0.46) | MAPTALDH1A1 | |
| SCHEMBL1871493 | 0.72 | MAPT (0.63) | PKMMAPTALDH1A1HSP90AA1KMT2A | |
| SCHEMBL6792448 | 0.69 | IKBKB (0.61) | MAPTALDH1A1HSP90AA1KMT2AIKBKB | |
| SCHEMBL11508407 | 0.68 | KDM4E (0.70) | PKMMAPTALDH1A1KMT2AHSD11B1 | |
| SCHEMBL32688151 | 0.68 | KDM4E (0.63) | PKMMAPTALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358749-A1 | 1,4-SUBSTITUTED-2,3,5,6-TETRAHYDRO 1,3,6]TRIAZOCINO 1,2-a]BENZIMIDAZOLES AND INTERMEDIATES THEREFOR | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-03-21 | — | — | EP | claimed |
| WO-1989008111-A1 | 1,4-SUBSTITUTED-2,3,5,6-TETRAHYDRO[1,3,6]TRIAZOCINO[1,2-a]BENZIMIDAZOLES AND INTERMEDIATES THEREFOR | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-09-08 | — | — | WO | claimed |
| US-4935515-A | ANTIARRHYTHMIA AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |
| US-4882323-A | ANTIARRYTHMIA AGENT INTERMEDIATES | AMERICAN HOME PRODUCTS (US) | 1989-11-21 | — | — | US | disclosed |