Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375808 | 0.81 | NOD1 (0.50) | ALDH1A1IKBKBCHUKPKMMAPT | |
| SCHEMBL9697096 | 0.77 | HSD11B1 (0.74) | ALDH1A1PKMMAPTHSD11B1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9695983 | 0.76 | HSD11B1 (0.73) | ALDH1A1PKMMAPTHSD11B1SMN1; SMN2 | |
| SCHEMBL10471768 | 0.74 | L3MBTL1 (0.56) | ALDH1A1IKBKBCHUKMAPTHSD11B1 | |
| SCHEMBL31249024 | 0.71 | KDM4E (0.61) | ALDH1A1PKMSMN1; SMN2KMT2AGAA | |
| SCHEMBL839645 | 0.71 | KDM4E (0.61) | ALDH1A1PKMSMN1; SMN2KMT2AGAA | |
| SCHEMBL840080 | 0.66 | KDM4E (0.63) | ALDH1A1PKMMAPTSMN1; SMN2MEN1 | |
| SCHEMBL32688151 | 0.66 | KDM4E (0.63) | ALDH1A1PKMMAPTSMN1; SMN2MEN1 | |
| SCHEMBL9695430 | 0.65 | POLB (0.46) | MAPTSMN1; SMN2LMNATSHRL3MBTL1 | |
| SCHEMBL840079 | 0.65 | KDM4E (0.64) | ALDH1A1PKMMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149700-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |
| WO-1991018904-A1 | SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |
| US-4935515-A | ANTIARRHYTHMIA AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |