Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.39 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.35 |
| ▸ | PYGL | P06737 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10376968 | 0.99 | PDE3B (0.39) | PDE3BPDE3ASMYD2PYGLALDH1A1 | |
| SCHEMBL10375064 | 0.99 | PDE3B (0.39) | PDE3BPDE3ASMYD2PYGLALDH1A1 | |
| SCHEMBL10376746 | 0.97 | PDE3B (0.41) | PDE3BPDE3ASMYD2PYGLALDH1A1 | |
| SCHEMBL10374640 | 0.89 | LMNA (0.40) | PYGLALDH1A1HTTNPSR1GAA | |
| SCHEMBL10754703 | 0.87 | PDE3B (0.42) | PDE3BPDE3AALDH1A1HTTNPSR1 | |
| SCHEMBL10756286 | 0.86 | PDE3B (0.42) | PDE3BPDE3AALDH1A1HTTNPSR1 | |
| SCHEMBL10755493 | 0.86 | PDE3B (0.42) | PDE3BPDE3AALDH1A1HTTNPSR1 | |
| SCHEMBL7310679 | 0.86 | PDE3B (0.38) | PDE3BPDE3AALDH1A1HTTNPSR1 | |
| SCHEMBL10375879 | 0.83 | PDE3B (0.36) | PDE3BPDE3AALDH1A1NPSR1PTGDR2 | |
| SCHEMBL7311387 | 0.83 | PDE3B (0.40) | PDE3BPDE3APYGLALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116948-B1 | (2-OXO-1,2,3,5-TETRAHYDROIMIDAZO-(2,1-B)QUINAZOLINYL)-OXYALKYL-AMIDES | SYNTEX (U.S.A.) INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4663320-A | ANTITUMOR AGENTS, ANTICOAGULANTS | SYNTEX (U.S.A.) INC. (US) | 1987-05-05 | — | — | US | disclosed |
| US-4551459-A | Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides | SYNTEX (U.S.A.) INC. (US) | 1985-11-05 | — | — | US | disclosed |
| US-4490371-A | ANTICOAGULANTS, PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0116948-A2 | (2-Oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkyl-amides | SYNTEX (U.S.A.) INC. (US) | 1984-08-29 | — | — | EP | disclosed |