Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10755493 | 1.00 | PDE3B (0.42) | PDE3BPDE3APDE2AP2RY12ALDH1A1 | |
| SCHEMBL10754703 | 0.99 | PDE3B (0.42) | PDE3BPDE3APDE2AP2RY12ALDH1A1 | |
| SCHEMBL10757796 | 0.89 | ALDH1A1 (0.41) | PDE3BPDE3APDE2AP2RY12ALDH1A1 | |
| SCHEMBL10376968 | 0.87 | PDE3B (0.39) | PDE3BPDE3AALDH1A1HTTNPSR1 | |
| SCHEMBL10375064 | 0.87 | PDE3B (0.39) | PDE3BPDE3AALDH1A1HTTNPSR1 | |
| SCHEMBL10375880 | 0.86 | PDE3B (0.39) | PDE3BPDE3AALDH1A1HTTNPSR1 | |
| SCHEMBL10376746 | 0.84 | PDE3B (0.41) | PDE3BPDE3AALDH1A1HTTNPSR1 | |
| SCHEMBL10753927 | 0.83 | PDE3B (0.44) | PDE3BPDE3APDE2AP2RY12ALDH1A1 | |
| SCHEMBL10752635 | 0.83 | PDE3B (0.44) | PDE3BPDE3APDE2AP2RY12ALDH1A1 | |
| SCHEMBL10376966 | 0.83 | MAPK1 (0.37) | PDE3BPDE3AALDH1A1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4690925-A | ANTITHROMBOTIC ACTIVITY, CARDIOTONIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0153152-A2 | (2-Oxo-1,2,3,5-tetrahydroimidazo-/2,1-b/quinnazolinyl)-oxyalkylamides, their preparation, compositions containing them and their use in making medicaments | SYNTEX (U.S.A.) INC. (US) | 1985-08-28 | — | — | EP | disclosed |