Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18713013 | 0.86 | LOX (0.53) | LOXLOXL2GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL18390563 | 0.86 | LOX (0.53) | LOXLOXL2GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL10375949 | 0.84 | HRH3 (0.47) | LOXLOXL2HRH3CXCR4SMN1; SMN2 | |
| SCHEMBL15214346 | 0.84 | HTR7 (0.52) | LOXLOXL2GAAHRH3POLB | |
| SCHEMBL13004099 | 0.84 | ALDH1A1 (0.45) | HRH3CXCR4SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL18705091 | 0.82 | KDM4E (0.49) | LOXLOXL2GAAHRH3ALDH1A1 | |
| SCHEMBL12767585 | 0.81 | LOX (0.48) | LOXLOXL2GAAALDH1A1 | |
| SCHEMBL9838916 | 0.81 | HRH3 (0.47) | HRH3CXCR4SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL21607858 | 0.81 | CXCR4 (0.52) | LOXLOXL2CHEK1GAACXCR4 | |
| SCHEMBL12677206 | 0.80 | LOX (0.47) | LOXLOXL2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117345-B1 | AMINOPYRIMIDINONES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-28 | — | — | EP | claimed |
| EP-0117345-A2 | Aminopyrimidinones as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-09-05 | — | — | EP | claimed |
| EP-0117345-B1 | AMINOPYRIMIDINONES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-28 | — | — | EP | disclosed |
| US-4567176-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-01-28 | — | — | US | disclosed |
| US-4540699-A | N-Substituted pyridinones having histamine H2 -antagonist activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-09-10 | — | — | US | disclosed |
| EP-0132914-A2 | Imidazolinone derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-02-13 | — | — | EP | disclosed |
| WO-1984004304-A1 | AMINOIMIDAZOLONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE FRENCH LAB (GB) | 1984-11-08 | — | — | WO | disclosed |
| EP-0117345-A2 | Aminopyrimidinones as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-09-05 | — | — | EP | disclosed |