Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 3/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10988785 | 0.77 | CCR1 (0.41) | MEN1KMT2A | |
| SCHEMBL10966709 | 0.76 | AKR1C3 (0.46) | MAPK14CASP1AKR1C3AKR1C2CHUK | |
| SCHEMBL9928999 | 0.74 | CSNK1A1 (0.43) | CASP1CSNK1A1CSNK1DCLK2CSNK1G1 | |
| SCHEMBL10965190 | 0.72 | CASP1 (0.38) | MAPK14CASP1ABCB1TOP2ATOP2B | |
| SCHEMBL10375231 | 0.71 | CCNC (0.44) | MAPK14CASP1AKR1C3AKR1C2CSNK1A1 | |
| SCHEMBL10965370 | 0.71 | MKNK2 (0.48) | CASP1CHUKJAK2JAK1TYK2 | |
| SCHEMBL7239423 | 0.70 | JAK2 (0.49) | CSNK1A1CSNK1DCLK2CSNK1G1MEN1 | |
| SCHEMBL9929024 | 0.70 | CSNK1A1 (0.37) | MAPK14CASP1CSNK1A1CSNK1DCLK2 | |
| SCHEMBL9928737 | 0.69 | CSNK1A1 (0.41) | CASP1CSNK1A1CSNK1DCLK2CSNK1G1 | |
| SCHEMBL2645320 | 0.67 | MAPK14 (0.54) | MAPK14AKR1C3AKR1C2CHUKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0160284-B1 | QUINO-BENOXAZINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-10-24 | — | — | EP | disclosed |
| EP-0162333-B1 | QUINO-BENZOTHIAZINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-06-27 | — | — | EP | disclosed |
| EP-0162333-A1 | Quino-benzothiazine antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-11-27 | — | — | EP | disclosed |
| EP-0160284-A1 | Quino-benoxazine antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-11-06 | — | — | EP | disclosed |
| US-4540694-A | 1-Pyridine substituted quino-benoxazines and antibacterial use | ABBOTT LABORATORIES (US) | 1985-09-10 | — | — | US | disclosed |
| US-4529725-A | 1-Pyridine substituted quino-benzothiazine | ABBOTT LABORATORIES (US) | 1985-07-16 | — | — | US | disclosed |