Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 4/20 | 0.44 |
| ▸ | CDK8 | P49336 | 4/20 | 0.44 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27996934 | 0.83 | CCNC (0.55) | CCNCCDK8NPC1MAPTRAB9A | |
| SCHEMBL6998722 | 0.76 | ADORA2B (0.43) | CCNCCDK8CYP46A1ADORA2BNPC1 | |
| SCHEMBL9208056 | 0.73 | ALDH1A1 (0.58) | CYP46A1CSNK1A1CSNK1DCLK2CSNK1G1 | |
| SCHEMBL19229926 | 0.72 | CYP46A1 (0.69) | CCNCCDK8CYP46A1CSNK1A1CSNK1D | |
| SCHEMBL10965370 | 0.72 | MKNK2 (0.48) | SMN1; SMN2CASP1JAK2JAK1TYK2 | |
| SCHEMBL2645320 | 0.71 | MAPK14 (0.54) | CYP46A1ADORA2BMAPK14MAPTAKR1C3 | |
| SCHEMBL10376115 | 0.71 | MAPK14 (0.38) | CCNCCDK8CSNK1A1CSNK1DCLK2 | |
| SCHEMBL10966709 | 0.71 | AKR1C3 (0.46) | CCNCCDK8CYP46A1MAPK14MAPT | |
| SCHEMBL28228315 | 0.69 | CCNC (0.44) | CCNCCDK8CSNK1DCLK2NPC1 | |
| SCHEMBL1395221 | 0.69 | ALDH1A1 (0.46) | CCNCCDK8CYP46A1ADORA2BCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162333-B1 | QUINO-BENZOTHIAZINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-06-27 | — | — | EP | disclosed |
| EP-0162333-A1 | Quino-benzothiazine antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-11-27 | — | — | EP | disclosed |
| US-4540694-A | 1-Pyridine substituted quino-benoxazines and antibacterial use | ABBOTT LABORATORIES (US) | 1985-09-10 | — | — | US | disclosed |
| US-4529725-A | 1-Pyridine substituted quino-benzothiazine | ABBOTT LABORATORIES (US) | 1985-07-16 | — | — | US | disclosed |