Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.67 |
| ▸ | HPGD | P15428 | 11/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.67 |
| ▸ | CASP3 | P42574 | 3/20 | 0.67 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.67 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 14/20 | 0.67 |
| ▸ | MEN1 | O00255 | 13/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 11/20 | 0.67 |
| ▸ | USP2 | O75604 | 3/20 | 0.67 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 10/20 | 0.57 |
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10358485 | 0.90 | MAPT (0.61) | MAPTHPGDSMN1; SMN2NPSR1CASP3 | |
| SCHEMBL10357577 | 0.86 | MEN1 (0.53) | MAPTHPGDSMN1; SMN2NPSR1CASP3 | |
| SCHEMBL10358038 | 0.85 | KMT2A (0.79) | MAPTHPGDSMN1; SMN2NPSR1CASP3 | |
| SCHEMBL10367183 | 0.84 | KMT2A (0.66) | MAPTHPGDSMN1; SMN2NPSR1CASP3 | |
| SCHEMBL10357921 | 0.84 | MAPT (0.48) | MAPTHPGDSMN1; SMN2NPSR1CASP3 | |
| SCHEMBL10358136 | 0.84 | HPGD (0.55) | MAPTHPGDSMN1; SMN2NPSR1CASP3 | |
| SCHEMBL10357267 | 0.83 | MAPT (0.90) | MAPTHPGDSMN1; SMN2NPSR1CASP3 | |
| SCHEMBL10357564 | 0.83 | MEN1 (0.47) | MAPTHPGDSMN1; SMN2NPSR1CASP3 | |
| SCHEMBL10372583 | 0.83 | MAPT (0.65) | MAPTHPGDSMN1; SMN2NPSR1CASP3 | |
| SCHEMBL10357282 | 0.83 | KMT2A (0.89) | MAPTHPGDSMN1; SMN2NPSR1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-19 | — | — | US | disclosed |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | MAPT 4385/4885HPGD 1340/4885SMN1; SMN2 4852/4885 |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | MAPT 4385/4885HPGD 1340/4885SMN1; SMN2 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.