Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 14/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 15/20 | 0.54 |
| ▸ | MAPT | P10636 | 13/20 | 0.54 |
| ▸ | MEN1 | O00255 | 13/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995433 | 0.85 | HPGD (0.69) | HPGDKMT2AMAPTMEN1ALOX15 | |
| SCHEMBL10376281 | 0.84 | MAPT (0.67) | HPGDKMT2AMAPTMEN1ALOX15 | |
| SCHEMBL10358273 | 0.81 | ALOX15 (0.63) | HPGDKMT2AMAPTMEN1ALOX15 | |
| SCHEMBL10358485 | 0.80 | MAPT (0.61) | HPGDKMT2AMAPTMEN1ALOX15 | |
| SCHEMBL10358589 | 0.76 | HPGD (0.64) | HPGDKMT2AMAPTMEN1ALOX15 | |
| SCHEMBL10358138 | 0.76 | KMT2A (0.59) | HPGDKMT2AMAPTMEN1ALOX15 | |
| SCHEMBL10358117 | 0.75 | HPGD (0.56) | HPGDKMT2AMAPTMEN1ALOX15 | |
| SCHEMBL10357278 | 0.75 | HPGD (0.56) | HPGDKMT2AMAPTMEN1ALOX15 | |
| SCHEMBL10357745 | 0.75 | MEN1 (0.64) | HPGDKMT2AMAPTMEN1ALOX15 | |
| SCHEMBL10357395 | 0.75 | MAPT (0.68) | HPGDKMT2AMAPTMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-19 | — | — | US | disclosed |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | HPGD 1340/4885KMT2A 4334/4885MAPT 4385/4885 |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | HPGD 1340/4885KMT2A 4334/4885MAPT 4385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.