Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377334 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTALOX15HPGD | |
| SCHEMBL10378897 | 0.87 | MAPT (0.48) | ALDH1A1MAPTHPGDNPSR1KMT2A | |
| SCHEMBL10378898 | 0.87 | MAPT (0.48) | ALDH1A1MAPTHPGDNPSR1KMT2A | |
| SCHEMBL10379107 | 0.84 | KMT2A (0.39) | ALDH1A1MAPTNPSR1KMT2ANPC1 | |
| SCHEMBL10377561 | 0.83 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTHPGDNPSR1 | |
| SCHEMBL10377660 | 0.82 | MAPT (0.46) | ALDH1A1KDM4EMAPTHPGDNPSR1 | |
| SCHEMBL10377357 | 0.82 | CYP1A2 (0.46) | KMT2ANPC1POLB | |
| SCHEMBL10377661 | 0.82 | MAPT (0.46) | ALDH1A1KDM4EMAPTHPGDNPSR1 | |
| SCHEMBL10377359 | 0.82 | CYP1A2 (0.46) | KMT2ANPC1POLB | |
| SCHEMBL10377662 | 0.81 | RECQL (0.43) | ALDH1A1KDM4EMAPTALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168037-B1 | 1-6-NAPHTHYRIDIN-2(1H)-ONES USEFUL AS CARDIOTONICS | STERLING DRUG INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| EP-0168037-A2 | 1-6-Naphthyridin-2(1H)-ones useful as cardiotonics | STERLING DRUG INC. (US) | 1986-01-15 | — | — | EP | disclosed |
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | disclosed |