Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.32 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377359 | 1.00 | CYP1A2 (0.46) | CYP1A2CYP2C19POLBKMT2AMEN1 | |
| SCHEMBL10377563 | 0.88 | ALDH1A1 (0.40) | KMT2AMEN1L3MBTL1NPC1ATM | |
| SCHEMBL10377561 | 0.88 | ALDH1A1 (0.40) | KMT2AMEN1L3MBTL1NPC1ATM | |
| SCHEMBL10378505 | 0.87 | LMNA (0.46) | KMT2AMEN1NPC1 | |
| SCHEMBL10379184 | 0.87 | LMNA (0.46) | KMT2AMEN1NPC1 | |
| SCHEMBL10377661 | 0.87 | MAPT (0.46) | CYP1A2CYP2C19KMT2AMEN1L3MBTL1 | |
| SCHEMBL10377660 | 0.87 | MAPT (0.46) | CYP1A2CYP2C19KMT2AMEN1L3MBTL1 | |
| SCHEMBL10377662 | 0.86 | RECQL (0.43) | CYP1A2CYP2C19POLBKMT2AMEN1 | |
| SCHEMBL10377663 | 0.86 | RECQL (0.43) | CYP1A2CYP2C19POLBKMT2AMEN1 | |
| SCHEMBL10378898 | 0.85 | MAPT (0.48) | CYP1A2CYP2C19POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168037-B1 | 1-6-NAPHTHYRIDIN-2(1H)-ONES USEFUL AS CARDIOTONICS | STERLING DRUG INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | disclosed |