Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4636008 | 0.79 | ALDH1A1 (0.41) | MAPTKDM4EPOLBALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL10377249 | 0.78 | DHFR (0.63) | MAPTKDM4EPOLBALDH1A1CYP1A2 | |
| SCHEMBL1617099 | 0.77 | CACNA1C (0.58) | MAPTKDM4EPOLBALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL10375280 | 0.76 | HTT (0.57) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL12716471 | 0.73 | KDM4E (0.50) | MAPTKDM4EPOLBRECQLALDH1A1 | |
| Hydrochloric Acid SCHEMBL10375255 | 0.71 | ALDH1A1 (0.47) | MAPTKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2333730 | 0.71 | HTT (0.59) | MAPTKDM4EPOLBALDH1A1CYP3A4 | |
| SCHEMBL10377728 | 0.70 | ALDH1A1 (0.56) | MAPTALDH1A1L3MBTL1GAAMEN1 | |
| SCHEMBL11691221 | 0.68 | KDM4E (0.56) | MAPTKDM4EPOLBALDH1A1CYP1A2 | |
| SCHEMBL18191095 | 0.68 | ALDH1A1 (0.43) | MAPTKDM4EPOLBALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169712-B1 | NEW PYRIMIDINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND COMPOSITION CONTAINING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-12-12 | — | — | EP | disclosed |
| US-4698340-A | TREATMENT OF CEREBROVASCULAR DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | disclosed |
| EP-0169712-A2 | New pyrimidine derivatives, processes for preparation thereof and composition containing the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-29 | — | — | EP | disclosed |