Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.35 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | CASP7 | P55210 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10376321 | 1.00 | PLA2G10 (0.35) | PLA2G10PLA2G5ADORA2BHSD17B10KDM4E | |
| SCHEMBL10635209 | 0.86 | PLA2G10 (0.43) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL9526436 | 0.86 | PLA2G10 (0.43) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL10378325 | 0.83 | PLA2G10 (0.36) | PLA2G10PLA2G5ADORA2BKDM4EALDH1A1 | |
| SCHEMBL10378448 | 0.83 | PLA2G10 (0.36) | PLA2G10PLA2G5ADORA2BKDM4EALDH1A1 | |
| SCHEMBL10376315 | 0.82 | ALDH1A1 (0.39) | PLA2G10PLA2G5HSD17B10KDM4EALDH1A1 | |
| SCHEMBL10376676 | 0.82 | ALDH1A1 (0.39) | PLA2G10PLA2G5HSD17B10KDM4EALDH1A1 | |
| SCHEMBL10638447 | 0.82 | ALDH1A1 (0.39) | PLA2G10PLA2G5HSD17B10KDM4EALDH1A1 | |
| SCHEMBL9525301 | 0.81 | KMT2A (0.41) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL10376336 | 0.79 | PLA2G10 (0.37) | PLA2G10PLA2G5ALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161801-B1 | PERHYDROTHIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANKYO COMPANY LIMITED (JP) | 1990-11-07 | — | — | EP | disclosed |
| EP-0365045-A1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1990-04-25 | — | — | EP | disclosed |
| US-4699905-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1987-10-13 | — | — | US | disclosed |
| EP-0161801-A2 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1985-11-21 | — | — | EP | disclosed |