Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.43 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10635209 | 1.00 | PLA2G10 (0.43) | PLA2G10PLA2G5RIPK1KDM4EALDH1A1 | |
| SCHEMBL9525301 | 0.88 | KMT2A (0.41) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL10376321 | 0.86 | PLA2G10 (0.35) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL10378356 | 0.86 | PLA2G10 (0.35) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL10638447 | 0.84 | ALDH1A1 (0.39) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL10376676 | 0.84 | ALDH1A1 (0.39) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL10376315 | 0.84 | ALDH1A1 (0.39) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL9526498 | 0.84 | KMT2A (0.40) | PLA2G10PLA2G5CCKBR | |
| SCHEMBL7341629 | 0.84 | FDFT1 (0.38) | — | |
| SCHEMBL7341637 | 0.84 | FDFT1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365045-B1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1993-12-01 | — | — | EP | disclosed |
| EP-0365045-A1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1990-04-25 | — | — | EP | disclosed |
| US-4778790-A | HYPOTENSIVE AGENTS | SANKYO COMPANY LIMITED (JP) | 1988-10-18 | — | — | US | disclosed |
| US-4699905-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1987-10-13 | — | — | US | disclosed |
| EP-0240366-A2 | Perhydrothiazepine and perhydroazepine derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1987-10-07 | — | — | EP | disclosed |
| EP-0161801-A2 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1985-11-21 | — | — | EP | disclosed |