Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10654513 | 0.88 | KAT2B (0.41) | EPHB4KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL10657534 | 0.87 | CYP1A2 (0.40) | KDM4EALDH1A1PDE4BPDE4DCYP1A2 | |
| SCHEMBL9629788 | 0.87 | KAT2B (0.45) | EPHB4KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL10377397 | 0.86 | PDE4A (0.39) | KDM4EALDH1A1HSD17B10PDE4BPDE4D | |
| SCHEMBL10657771 | 0.84 | PDE4B (0.39) | EPHB4KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL10377181 | 0.81 | EPHB4 (0.48) | EPHB4PDE4BPDE4DCYP1A2PDE4A | |
| SCHEMBL10379155 | 0.79 | HPGD (0.36) | KDM4EALDH1A1HSD17B10TSHRPDE4B | |
| SCHEMBL10653938 | 0.79 | EPHB4 (0.52) | EPHB4KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL10655387 | 0.78 | SMN1; SMN2 (0.44) | KDM4EALDH1A1HSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL10379024 | 0.76 | PKM (0.45) | KDM4EALDH1A1HSD17B10TSHRPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127135-B1 | FUSED TRICYCLIC DERIVATIVES OF NAPHTHYRIDINONE AND PYRIDONE AND THE CORRESPONDING THIONES | SCHERING CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |