Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 3/20 | 0.34 |
| ▸ | LITAF | Q99732 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377397 | 0.88 | PDE4A (0.39) | CYP1A2MEN1HPGDKMT2APDE4B | |
| SCHEMBL10378751 | 0.87 | EPHB4 (0.45) | CYP1A2MAPTHPGDPDE4BPDE4D | |
| SCHEMBL10657718 | 0.87 | MEN1 (0.40) | CYP1A2MAPTCYP2C19MEN1HPGD | |
| SCHEMBL10657771 | 0.86 | PDE4B (0.39) | MAPTHPGDPDE4BPDE4DALDH1A1 | |
| SCHEMBL9630898 | 0.86 | HPGD (0.49) | CYP1A2MAPTCYP2C19MEN1HPGD | |
| SCHEMBL10379155 | 0.81 | HPGD (0.36) | CYP1A2MAPTCYP2C19MEN1HPGD | |
| SCHEMBL10657589 | 0.79 | MAPT (0.39) | CYP1A2MAPTCYP2C19MEN1HPGD | |
| SCHEMBL9629709 | 0.77 | HPGD (0.40) | CYP1A2MAPTCYP2C19MEN1HPGD | |
| SCHEMBL10662007 | 0.77 | ALDH1A1 (0.39) | CYP1A2MAPTCYP2C19MEN1HPGD | |
| SCHEMBL10657767 | 0.77 | CREBBP (0.38) | CYP1A2CYP2C19HPGDALDH1A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |