Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630915 | 0.91 | HPGD (0.38) | HPGDMAPTPDE4BPDE4DPDE4A | |
| SCHEMBL9629995 | 0.90 | FEN1 (0.44) | PDE4BPDE4DPDE4AKCNH2CYP2C19 | |
| SCHEMBL9629150 | 0.89 | MAPT (0.46) | HPGDMAPTPDE4BPDE4DPDE4A | |
| SCHEMBL9629009 | 0.89 | HPGD (0.44) | HPGDPDE4BPDE4DEP300CREBBP | |
| SCHEMBL10377455 | 0.88 | KAT2B (0.40) | HPGDMAPTPDE4BPDE4DKAT2B | |
| SCHEMBL10379103 | 0.88 | PDE4B (0.42) | HPGDMAPTPDE4BPDE4DCYP2C19 | |
| SCHEMBL10378770 | 0.87 | PKM (0.43) | MAPTPDE4BKAT2BKCNH2CYP2C19 | |
| SCHEMBL10378427 | 0.84 | PTPN11 (0.38) | HPGDMAPTKCNH2CYP2C19CYP1A2 | |
| SCHEMBL10378372 | 0.82 | HPGD (0.47) | HPGDMAPTPDE4BPDE4DEP300 | |
| SCHEMBL10654559 | 0.81 | DRD1 (0.41) | HPGDCREBBPKMT2AALDH1A1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127135-B1 | FUSED TRICYCLIC DERIVATIVES OF NAPHTHYRIDINONE AND PYRIDONE AND THE CORRESPONDING THIONES | SCHERING CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |