Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.41 |
| ▸ | DRD5 | P21918 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | USP14 | P54578 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LIG1 | P18858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10658309 | 0.90 | KDM4E (0.41) | DRD1DRD5HPGDLMNACREBBP | |
| SCHEMBL10659381 | 0.88 | DRD1 (0.42) | DRD1DRD5HPGDLMNACREBBP | |
| SCHEMBL10659321 | 0.88 | HKDC1 (0.41) | HPGDUSP14LMNACREBBPBRD4 | |
| SCHEMBL10378796 | 0.81 | HPGD (0.44) | DRD1DRD5HPGDCREBBPALDH1A1 | |
| SCHEMBL10660933 | 0.79 | SMN1; SMN2 (0.41) | LMNACREBBPBRD4SMN1; SMN2KMT2A | |
| SCHEMBL10657775 | 0.79 | HPGD (0.37) | DRD1DRD5HPGDLMNACREBBP | |
| SCHEMBL10654076 | 0.78 | HPGD (0.50) | DRD1DRD5HPGDLMNAALDH1A1 | |
| SCHEMBL10659035 | 0.76 | HPGD (0.40) | DRD1DRD5HPGDUSP14LMNA | |
| SCHEMBL10657764 | 0.74 | HPGD (0.38) | HPGDLMNACREBBPBRD4ALDH1A1 | |
| SCHEMBL10658199 | 0.74 | P2RX4 (0.55) | DRD1HPGDALDH1A1DHFRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |