Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.52 |
| ▸ | FYN | P06241 | 4/20 | 0.51 |
| ▸ | MET | P08581 | 3/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 8/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3122060 | 0.87 | MET (0.62) | MAP4K4FYNMETCHEK2CHEK1 | |
| SCHEMBL10380733 | 0.86 | MET (0.53) | MAP4K4FYNMETUSP7 | |
| SCHEMBL30454464 | 0.79 | MAP4K4 (0.71) | MAP4K4MET | |
| SCHEMBL487688 | 0.79 | MAP4K4 (0.71) | MAP4K4MET | |
| SCHEMBL30453201 | 0.78 | MAP4K4 (0.64) | MAP4K4MET | |
| SCHEMBL487982 | 0.78 | MAP4K4 (0.64) | MAP4K4MET | |
| SCHEMBL488366 | 0.78 | MET (0.59) | MAP4K4MET | |
| SCHEMBL30452529 | 0.77 | MET (0.73) | MAP4K4FYNMETCHEK2USP7 | |
| SCHEMBL487592 | 0.77 | MET (0.73) | MAP4K4FYNMETCHEK2USP7 | |
| SCHEMBL5480970 | 0.76 | MET (0.53) | MAP4K4FYNMETCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2476667-A2 | Aminoheteroaryl compounds as protein kinase inhibitors | Sugen, Inc. (US) | 2012-07-18 | — | — | EP | disclosed |