Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.53 |
| ▸ | FYN | P06241 | 4/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10382252 | 0.86 | MAP4K4 (0.52) | METFYNMAP4K4USP7 | |
| SCHEMBL10215090 | 0.83 | JAK2 (0.58) | METJAK2MAP4K3 | |
| SCHEMBL487592 | 0.80 | MET (0.73) | METFYNMAP4K4TGFBR1USP7 | |
| SCHEMBL30452529 | 0.80 | MET (0.73) | METFYNMAP4K4TGFBR1USP7 | |
| SCHEMBL488409 | 0.78 | MET (0.48) | METFYNMAP4K4JAK2MAP4K3 | |
| SCHEMBL3122066 | 0.78 | MET (0.56) | METFYNMAP4K4JAK2MAP4K3 | |
| SCHEMBL487622 | 0.77 | MET (0.52) | METFYNMAP4K4JAK2MAP4K3 | |
| SCHEMBL487796 | 0.76 | MET (0.57) | METFYNMAP4K4JAK2MAP4K3 | |
| SCHEMBL487559 | 0.76 | MET (0.53) | METFYNMAP4K4JAK2MAP4K3 | |
| SCHEMBL27630181 | 0.75 | MET (0.51) | METFYNMAP4K4JAK2MAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2476667-A2 | Aminoheteroaryl compounds as protein kinase inhibitors | Sugen, Inc. (US) | 2012-07-18 | — | — | EP | disclosed |