Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 3/20 | 0.47 |
| ▸ | SKP1 | P63208 | 3/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 4/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10444974 | 0.89 | LMNA (0.49) | CKS1BSKP1SKP2ALDH1A1RAB9A | |
| SCHEMBL10512713 | 0.89 | TDP1 (0.49) | CKS1BSKP1SKP2ALDH1A1RAB9A | |
| SCHEMBL10444952 | 0.89 | CKS1B (0.41) | CKS1BSKP1SKP2ALDH1A1RAB9A | |
| SCHEMBL10512191 | 0.89 | L3MBTL1 (0.49) | ALDH1A1RAB9ASMN1; SMN2L3MBTL1CNR1 | |
| SCHEMBL10509956 | 0.85 | TDP1 (0.53) | ALDH1A1RAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL10445086 | 0.85 | ADORA1 (0.45) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL10509045 | 0.85 | NPSR1 (0.53) | ALDH1A1RAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL10444961 | 0.85 | CKS1B (0.53) | CKS1BSKP1SKP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL10510072 | 0.81 | ADORA2A (0.48) | ALDH1A1SMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL11679597 | 0.79 | CKS1B (0.53) | CKS1BSKP1SKP2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4978662-A | 2-substituted trimethylpyrazine derivatives as inhibitors of platelet function | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 1990-12-18 | — | — | US | disclosed |
| EP-0194686-B1 | PYRAZINE DERIVATIVES | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION (JP) | 1989-12-20 | — | — | EP | disclosed |
| US-4788197-A | ANTICOAGULANTS | TERUMO KABUSHIKI KAISHA (JP) | 1988-11-29 | — | — | US | disclosed |
| US-4788197-A | ANTICOAGULANTS | TERUMO KABUSHIKI KAISHA (JP) | 1988-11-29 | — | — | US | disclosed |
| EP-0194686-A1 | Pyrazine derivatives | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION (JP) | 1986-09-17 | — | — | EP | disclosed |
| EP-0194686-A1 | Pyrazine derivatives | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION (JP) | 1986-09-17 | — | — | EP | disclosed |