SCHEMBL1038650

SCHEMBL1038650

COc1cccc(-c2nccc3ccccc23)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.55
CLK4 Q9HAZ1 3/20 0.53
DYRK1A Q13627 1/20 0.53
PDE10A Q9Y233 3/20 0.50
CYP1A2 P05177 7/20 0.49
CYP2C9 P11712 4/20 0.49
CYP3A4 P08684 4/20 0.49
CYP2B6 P20813 3/20 0.49
AHR P35869 3/20 0.49
NR1I3 Q14994 3/20 0.49
VDR P11473 2/20 0.49
MAPK13 O15264 1/20 0.47
RAF1 P04049 1/20 0.47
MAPK12 P53778 1/20 0.47
MAPK11 Q15759 1/20 0.47
MAPK14 Q16539 1/20 0.47
ADORA1 P30542 2/20 0.47
KMT2A Q03164 3/20 0.47
KDM4E B2RXH2 1/20 0.47
NPC1 O15118 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29808138 1.00 ADORA2A (0.55) ADORA2ACLK4DYRK1APDE10ACYP1A2
SCHEMBL28426686 0.92 ADORA2A (0.48) ADORA2ACLK4DYRK1APDE10ACYP1A2
SCHEMBL28420591 0.92 ADORA2A (0.48) ADORA2ACLK4DYRK1APDE10ACYP1A2
SCHEMBL11886387 0.90 CYP1A2 (0.56) ADORA2ACLK4DYRK1APDE10ACYP1A2
SCHEMBL7005152 0.88 CYP2A6 (0.53) ADORA2ACYP1A2CYP2C9CYP3A4CYP2B6
SCHEMBL31536244 0.87 CYP11B2 (0.55) CYP1A2CYP2C9CYP3A4CYP2B6KDM4E
SCHEMBL17449880 0.84 KDM4E (0.57) CYP1A2CYP3A4KMT2AKDM4ENPC1
SCHEMBL29607745 0.84 KDM4E (0.57) CYP1A2CYP3A4KMT2AKDM4ENPC1
SCHEMBL6449738 0.83 NPC1 (0.64) CYP1A2CYP2C9CYP3A4KMT2ANPC1
SCHEMBL7005328 0.83 MAPT (0.52) PDE10ACYP1A2CYP2C9CYP3A4KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035398-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES UNIV ARIZONA STATE (US) 2026-02-05 US disclosed
US-12312366-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2025-05-27 US disclosed
US-20230115701-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES UNIV ARIZONA STATE (US) 2023-04-13 US disclosed
US-20230115701-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES UNIV ARIZONA STATE (US) 2023-04-13 US disclosed
CN-115448957-A Novel tetradentate platinum complexes 通用显示公司 2022-12-09 CN disclosed
US-11472827-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2022-10-18 US disclosed
CN-111732611-B Novel tetradentate platinum complexes 通用显示公司 2022-08-23 CN disclosed
US-20210024559-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES UNIV ARIZONA STATE (US) 2021-01-28 US disclosed
US-20210024559-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES UNIV ARIZONA STATE (US) 2021-01-28 US disclosed
US-10836785-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-11-17 US disclosed
US-7608677-B2 Method for preparing polymeric organic iridium compositions GENERAL ELECTRIC COMPANY (US) 2009-10-27 US disclosed
EP-2049555-A2 ORGANIC IRIDIUM COMPOSITIONS AND THEIR USE IN ELECTRONIC DEVICES GENERAL ELECTRIC COMPANY (US) 2009-04-22 EP disclosed
WO-2008101842-A1 ELECTROLUMINESCENT METAL COMPLEXES WITH BENZOTRIAZOLES BASF SE (CH) 2008-08-28 WO disclosed
US-20080023672-A1 Organic iridium compositions and their use in electronic devices GENERAL ELECTRIC COMPANY 2008-01-31 US disclosed
US-20080026249-A1 Electronic devices comprising organic iridium compositions GENERAL ELECTRIC COMPANY 2008-01-31 US disclosed
US-20080026250-A1 Electronic devices comprising organic iridium compositions GENERAL ELECTRIC COMPANY 2008-01-31 US disclosed
US-20080023671-A1 Organic iridium compositions and their use in electronic devices GENERAL ELECTRIC COMPANY 2008-01-31 US disclosed
US-20080027028-A1 Ketopyrroles useful as ligands in organic iridium compositions GENERAL ELECTRIC COMPANY 2008-01-31 US disclosed
US-20080026477-A1 Method for preparing polymeric organic iridium compositions GENERAL ELECTRIC COMPANY (US) 2008-01-31 US disclosed
WO-2008014037-A2 ORGANIC IRIDIUM COMPOSITIONS AND THEIR USE IN ELECTRONIC DEVICES GENERAL ELECTRIC COMPANY (US) 2008-01-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10836785-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues PAICS, DNTT, PNPO ADORA2A 3140/4885CLK4 2842/4885DYRK1A 2089/4885
US-20260035398-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES LBR, SCO2, RAD54L ADORA2A 2579/4885CLK4 1830/4885DYRK1A 950/4885
US-20230115701-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES PAICS, DNTT, PNPO ADORA2A 3140/4885CLK4 2842/4885DYRK1A 2089/4885
US-20080027028-A1 Ketopyrroles useful as ligands in organic iridium compositions OR10J3, OPRD1, OCIAD1 ADORA2A 2629/4885CLK4 1203/4885DYRK1A 916/4885
US-12312366-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues PAICS, DNTT, PNPO ADORA2A 3140/4885CLK4 2842/4885DYRK1A 2089/4885
US-11472827-B2 Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues PAICS, DNTT, PNPO ADORA2A 3140/4885CLK4 2842/4885DYRK1A 2089/4885
US-20210024559-A1 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES PAICS, DNTT, PNPO ADORA2A 3140/4885CLK4 2842/4885DYRK1A 2089/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.