Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10388046 | 0.86 | CA2 (0.38) | CA2CA1CA4CA7 | |
| SCHEMBL10388257 | 0.79 | CA2 (0.38) | CA2ALDH1A1LMNAMAPK1 | |
| SCHEMBL9829741 | 0.79 | CNR1 (0.53) | CA2 | |
| SCHEMBL10388459 | 0.72 | CA2 (0.39) | CA2CA1CA4CA7LMNA | |
| SCHEMBL10387660 | 0.68 | CA2 (0.39) | CA2CA1CA4CA7LMNA | |
| SCHEMBL10388222 | 0.66 | CA2 (0.32) | CA2 | |
| SCHEMBL10387650 | 0.65 | CA2 (0.40) | CA2 | |
| SCHEMBL10388220 | 0.64 | CA2 (0.31) | CA2 | |
| SCHEMBL10388221 | 0.64 | CA2 (0.42) | CA2 | |
| SCHEMBL10387587 | 0.64 | CA2 (0.30) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4929637-A | CARBONIC ANHYDRASE INHIBITORS, VISION DEFECTS | MERCK & CO., INC. (US) | 1990-05-29 | — | — | US | disclosed |
| EP-0228237-B1 | SUBSTITUTED THIOPHENE-2-SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1989-11-23 | — | — | EP | disclosed |
| EP-0228237-A1 | Substituted thiophene-2-sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1987-07-08 | — | — | EP | disclosed |