Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 8/20 | 0.53 |
| ▸ | CA2 | P00918 | 5/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828921 | 0.84 | CA2 (0.52) | CNR1CA2CFTRGAAHSD17B10 | |
| SCHEMBL9828296 | 0.83 | CA2 (0.47) | CNR1CA2LOXPKM | |
| SCHEMBL9829857 | 0.82 | CNR1 (0.44) | CNR1CA2ACACBGAAPKM | |
| SCHEMBL10388231 | 0.79 | CA2 (0.39) | CA2 | |
| SCHEMBL10388046 | 0.77 | CA2 (0.38) | CA2ACACB | |
| SCHEMBL9827840 | 0.75 | CA2 (0.58) | CA2CFTRGAALOXPKM | |
| SCHEMBL9831048 | 0.72 | CA2 (0.43) | CA2 | |
| SCHEMBL9830133 | 0.70 | CA2 (0.49) | CA2GAAPKM | |
| SCHEMBL4446314 | 0.65 | ACACB (0.82) | CNR1ACACB | |
| SCHEMBL4446311 | 0.65 | ACACB (0.82) | CNR1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |