Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | FADS1 | O60427 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821586 | 0.90 | MAPT (0.73) | MAPTMAPK1HTTNPC1POLB | |
| SCHEMBL10948187 | 0.90 | KEAP1 (0.63) | MAPTMAPK1HTTNPC1POLB | |
| SCHEMBL28594338 | 0.86 | MAPT (0.83) | MAPTMAPK1HTTNPC1POLB | |
| SCHEMBL2473546 | 0.84 | KEAP1 (0.67) | MAPTMAPK1HTTPOLBKEAP1 | |
| SCHEMBL29611914 | 0.84 | KEAP1 (0.67) | MAPTMAPK1HTTPOLBKEAP1 | |
| SCHEMBL5963060 | 0.83 | KEAP1 (0.56) | MAPTMAPK1HTTNPC1POLB | |
| SCHEMBL2473605 | 0.80 | MAPT (0.67) | MAPTMAPK1HTTNPC1POLB | |
| SCHEMBL344086 | 0.80 | LTA4H (0.58) | MAPTMAPK1HTTNPC1POLB | |
| SCHEMBL10396945 | 0.80 | MAPT (1.00) | MAPTMAPK1HTTNPC1POLB | |
| SCHEMBL11508307 | 0.80 | NPC1 (0.53) | MAPTMAPK1HTTNPC1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4898874-A | Acetic acid derivatives of 3-aryl-2,1-benzisoxazole and esters and amides thereof | A. H. ROBINS COMPANY, INC. (US) | 1990-02-06 | — | — | US | disclosed |
| EP-0260924-A1 | Antiinflammatory derivatives of 3-aryl-2,1-benzisoxazole | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-03-23 | — | — | EP | disclosed |