Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.32 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31001160 | 0.75 | ALDH1A1 (0.46) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10396913 | 0.73 | IP6K1 (0.47) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5044710 | 0.71 | ELANE (0.41) | ELANEALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL5707682 | 0.70 | ALDH1A1 (0.46) | ELANEALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL6691319 | 0.70 | ALDH1A1 (0.55) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10396386 | 0.70 | ALDH1A1 (0.44) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL31040367 | 0.69 | IDO1 (0.37) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2492556 | 0.69 | ALDH1A1 (0.62) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1309790 | 0.69 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL10892049 | 0.66 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4898874-A | Acetic acid derivatives of 3-aryl-2,1-benzisoxazole and esters and amides thereof | A. H. ROBINS COMPANY, INC. (US) | 1990-02-06 | — | — | US | disclosed |
| EP-0260924-A1 | Antiinflammatory derivatives of 3-aryl-2,1-benzisoxazole | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-03-23 | — | — | EP | disclosed |