SCHEMBL2492556

SCHEMBL2492556

c1ccc(-c2onc3ccccc23)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.62
SMN1; SMN2 Q16637 2/20 0.62
HPGD P15428 1/20 0.62
IP6K1 Q92551 13/20 0.57
IP6K2 Q9UHH9 10/20 0.57
IP6K3 Q96PC2 9/20 0.57
MEN1 O00255 3/20 0.57
KMT2A Q03164 3/20 0.57
POLB P06746 3/20 0.57
TP53 P04637 2/20 0.57
HSD17B10 Q99714 2/20 0.57
NPC1 O15118 2/20 0.57
KDM4E B2RXH2 2/20 0.57
TSHR P16473 2/20 0.54
LMNA P02545 2/20 0.54
USP2 O75604 1/20 0.54
MAPT P10636 1/20 0.54
ALOX15 P16050 1/20 0.54
MAPK1 P28482 1/20 0.54
RAB9A P51151 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6691319 0.93 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2HPGDIP6K1IP6K2
SCHEMBL31001160 0.86 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2HPGDIP6K1IP6K2
SCHEMBL23458464 0.86 IP6K1 (0.51) ALDH1A1SMN1; SMN2HPGDIP6K1IP6K2
SCHEMBL1837436 0.84 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2HPGDIP6K1IP6K2
SCHEMBL8655645 0.84 MEN1 (0.56) ALDH1A1SMN1; SMN2HPGDIP6K1IP6K2
SCHEMBL10397089 0.84 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2HPGDIP6K1IP6K2
SCHEMBL28602742 0.84 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2HPGDIP6K1IP6K2
SCHEMBL10396726 0.80 IP6K1 (0.62) ALDH1A1SMN1; SMN2HPGDIP6K1IP6K2
SCHEMBL29080634 0.80 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2HPGDIP6K1IP6K2
SCHEMBL10396913 0.80 IP6K1 (0.47) ALDH1A1SMN1; SMN2HPGDIP6K1IP6K2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0892846-B1 BLEACHING POWER ENHANCERS FOR BLEACHES AND TEXTILE WASHING COMPOSITIONS BASF AG (DE) 2002-10-23 EP claimed
US-6130198-A Bleaching efficiency boosters for bleach and textile detergent compositions BASF AKTIENGESELLSCHAFT (DE) 2000-10-10 US claimed
EP-0570714-B1 Use of aminoalcohol-N-acylderivatives for the manufacture of a medicament for the treatment of neurogenic endoneural oedema of the peripheral nerve LIFEGROUP SPA (IT) 1999-09-01 EP claimed
EP-0892846-A1 BLEACHING POWER ENHANCERS FOR BLEACHES AND TEXTILE WASHING COMPOSITIONS BASF AKTIENGESELLSCHAFT (DE) 1999-01-27 EP claimed
WO-1997035950-A1 BLEACHING POWER ENHANCERS FOR BLEACHES AND TEXTILE WASHING COMPOSITIONS BASF AKTIENGESELLSCHAFT (DE) 1997-10-02 WO claimed
CN-115475541-A Poly (quinoline) film 恩特格里斯公司 2022-12-16 CN disclosed
US-9868722-B2 Monocyclic pyrimidine/pyridine compounds as inhibitors of P97 complex CLEAVE BIOSCIENCES, INC. (US) 2018-01-16 US disclosed
US-20160304495-A1 MONOCYCLIC PYRIMIDINE/PYRIDINE COMPOUNDS AS INHIBITORS OF P97 COMPLEX CLEAVE BIOSCIENCES, INC. (US) 2016-10-20 US disclosed
EP-3016984-A2 USE OF A GEL-LIKE POLYMER COMPOSITION WHICH CAN BE OBTAINED BY POLYMERIZING AN ACID GROUP-CONTAINING MONOMER IN THE PRESENCE OF A POLYETHER COMPOUND IN FORMULATIONS FOR AUTOMATIC DISHWASHING BASF SE (DE) 2016-05-11 EP disclosed
US-9273012-B2 Facile preparation of 4-substituted quinazolines and related heterocycles UNIVERSITY OF HOUSTON SYSTEM (US) 2016-03-01 US disclosed
WO-2015000969-A2 USE OF A GEL-LIKE POLYMER COMPOSITION WHICH CAN BE OBTAINED BY POLYMERIZING AN ACID GROUP-CONTAINING MONOMER IN THE PRESENCE OF A POLYETHER COMPOUND IN FORMULATIONS FOR AUTOMATIC DISHWASHING BASF SE (DE) 2015-01-08 WO disclosed
WO-2012151141-A2 A FACILE PREPARATION OF 4-SUBSTITUTED QUINAZOLINES AND RELATED HETEROCYCLES UNIVERSITY OF HOUSTON SYSTEM (US) 2012-11-08 WO disclosed
WO-2002014266-A1 METHOD FOR PRODUCING ALKYL ARYL SULPHONATES BASF AKTIENGESELLSCHAFT (DE) 2002-02-21 WO disclosed
US-20010031869-A1 Processes and synthetic intermediates for preparing N-arylacridancarboxylic acid derivatives LUMIGEN, INC. 2001-10-18 US disclosed
US-6130198-A Bleaching efficiency boosters for bleach and textile detergent compositions BASF AKTIENGESELLSCHAFT (DE) 2000-10-10 US disclosed
EP-0958345-A2 ACTIVATORS FOR PER COMPOUNDS ORACLE CORPORATION (US) 1999-11-24 EP disclosed
EP-0892846-A1 BLEACHING POWER ENHANCERS FOR BLEACHES AND TEXTILE WASHING COMPOSITIONS BASF AKTIENGESELLSCHAFT (DE) 1999-01-27 EP disclosed
WO-1998033878-A2 ACTIVATORS FOR PER COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 1998-08-06 WO disclosed
WO-1997035950-A1 BLEACHING POWER ENHANCERS FOR BLEACHES AND TEXTILE WASHING COMPOSITIONS BASF AKTIENGESELLSCHAFT (DE) 1997-10-02 WO disclosed
US-3931172-A 1-Tertiary-butyl-3-morpholino-3-phenyl-2,1-benzisoxaxolines SANDOZ INC. (US) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160304495-A1 MONOCYCLIC PYRIMIDINE/PYRIDINE COMPOUNDS AS INHIBITORS OF P97 COMPLEX PSMG3, PSMD2, PSME1 ALDH1A1 2684/4885SMN1; SMN2 2135/4885HPGD 2966/4885
US-20010031869-A1 Processes and synthetic intermediates for preparing N-arylacridancarboxylic acid derivatives ALDH3A1, AADAC, SPR ALDH1A1 64/4885SMN1; SMN2 4285/4885HPGD 318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.