Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | PTAFR | P25105 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399270 | 1.00 | CES2 (0.49) | CES2CES1TP53MAPTGAA | |
| SCHEMBL10399215 | 0.89 | KDM4E (0.43) | MAPTGAATDP1PTAFRKDM4E | |
| SCHEMBL10399212 | 0.89 | KDM4E (0.43) | MAPTGAATDP1PTAFRKDM4E | |
| SCHEMBL10398771 | 0.89 | MAPT (0.43) | MAPTGAATDP1ALDH1A1PTAFR | |
| SCHEMBL10398772 | 0.89 | MAPT (0.43) | MAPTGAATDP1ALDH1A1PTAFR | |
| SCHEMBL10398911 | 0.88 | CES2 (0.49) | CES2CES1MAPTGAAALDH1A1 | |
| SCHEMBL10398910 | 0.88 | CES2 (0.49) | CES2CES1MAPTGAAALDH1A1 | |
| SCHEMBL10399397 | 0.88 | MAPT (0.51) | TP53MAPTGAATDP1ALDH1A1 | |
| SCHEMBL10398998 | 0.88 | MAPT (0.51) | TP53MAPTGAATDP1ALDH1A1 | |
| SCHEMBL10399000 | 0.88 | MAPT (0.51) | TP53MAPTGAATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4975438-A | ANTICOAGULANT | HOFFMANN-LA ROCHE INC. (US) | 1990-12-04 | — | — | US | disclosed |
| US-4788206-A | CARDIOVASCULAR DISORDERS, PLATELETS | HOFFMANN-LA ROCHE INC. (US) | 1988-11-29 | — | — | US | disclosed |