SCHEMBL10397708

SCHEMBL10397708

C=CC=CC(=O)N(c1ccc(F)cc1)C(C)CCCc1cccnc1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTAFR P25105 17/20 0.51
TBXAS1 P24557 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10398980 0.83 PTAFR (0.54) PTAFR
SCHEMBL10673055 0.73 PTAFR (0.70) PTAFR
SCHEMBL10514365 0.73 PTAFR (0.53) PTAFR
SCHEMBL10397706 0.70 PTAFR (0.66) PTAFR
SCHEMBL10397710 0.70 PTAFR (0.66) PTAFR
SCHEMBL9521018 0.67 PTAFR (1.00) PTAFR
SCHEMBL10399003 0.67 PTAFR (1.00) PTAFR
SCHEMBL9519576 0.67 PTAFR (1.00) PTAFR
SCHEMBL10666702 0.67 PTAFR (0.49) PTAFRTBXAS1
SCHEMBL10398021 0.67 PTAFR (0.51) PTAFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4975438-A ANTICOAGULANT HOFFMANN-LA ROCHE INC. (US) 1990-12-04 US disclosed
US-4788206-A CARDIOVASCULAR DISORDERS, PLATELETS HOFFMANN-LA ROCHE INC. (US) 1988-11-29 US disclosed