Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | BMP1 | P13497 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040348 | 0.93 | AXL (0.39) | AXLMERTKTHRBTP53REN | |
| SCHEMBL1038353 | 0.92 | AXL (0.40) | AXLMERTKTHRBTP53REN | |
| SCHEMBL1039408 | 0.92 | AXL (0.39) | AXLMERTKTHRBTP53REN | |
| SCHEMBL1039349 | 0.92 | AXL (0.39) | AXLMERTKTHRBTP53REN | |
| SCHEMBL1040333 | 0.92 | AXL (0.40) | AXLMERTKTHRBTP53REN | |
| SCHEMBL1039394 | 0.91 | AXL (0.38) | AXLMERTKTHRBTP53REN | |
| SCHEMBL1039721 | 0.91 | AXL (0.37) | AXLMERTKTHRBTP53REN | |
| SCHEMBL1035197 | 0.91 | REN (0.38) | THRBTP53RENMAPTCYP3A4 | |
| SCHEMBL1040042 | 0.91 | AXL (0.38) | AXLMERTKTHRBTP53REN | |
| SCHEMBL1040324 | 0.89 | MMP9 (0.36) | THRBTP53RENBMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049514-B1 | NITRATE ESTERS OF PIPERIDINES | NOVARTIS AG (CH) | 2011-01-26 | — | — | EP | disclosed |