Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.63 |
| ▸ | STAT3 | P40763 | 1/20 | 0.63 |
| ▸ | F3 | P13726 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 4/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410058 | 1.00 | HDAC8 (0.63) | HDAC8HDAC6STAT3F3THRB | |
| SCHEMBL2009524 | 0.87 | F3 (0.72) | HDAC8HDAC6F3THRBATM | |
| SCHEMBL1383345 | 0.87 | F3 (0.72) | HDAC8HDAC6F3THRBATM | |
| SCHEMBL1231600 | 0.84 | THRB (0.77) | HDAC8HDAC6STAT3F3THRB | |
| SCHEMBL2026112 | 0.84 | HDAC8 (0.65) | HDAC8HDAC6STAT3F3THRB | |
| SCHEMBL2026113 | 0.84 | HDAC8 (0.65) | HDAC8HDAC6STAT3F3THRB | |
| SCHEMBL1231605 | 0.84 | THRB (0.77) | HDAC8HDAC6STAT3F3THRB | |
| SCHEMBL25307242 | 0.83 | THRB (0.74) | HDAC8HDAC6STAT3F3THRB | |
| SCHEMBL21428246 | 0.83 | HDAC8 (0.68) | HDAC8HDAC6STAT3F3THRB | |
| SCHEMBL13067871 | 0.83 | HDAC8 (0.69) | HDAC8HDAC6F3THRBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4975438-A | ANTICOAGULANT | HOFFMANN-LA ROCHE INC. (US) | 1990-12-04 | — | — | US | claimed |
| US-4975438-A | ANTICOAGULANT | HOFFMANN-LA ROCHE INC. (US) | 1990-12-04 | — | — | US | disclosed |