SCHEMBL1383345

SCHEMBL1383345

COc1ccc(C=CC(N)=O)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F3 P13726 3/20 0.72
THRB P10828 1/20 0.70
ATM Q13315 1/20 0.70
GSK3B P49841 2/20 0.68
HDAC3 O15379 2/20 0.66
HDAC1 Q13547 2/20 0.66
HDAC2 Q92769 2/20 0.66
HDAC8 Q9BY41 2/20 0.66
HDAC6 Q9UBN7 2/20 0.66
BACE1 P56817 1/20 0.62
HDAC4 P56524 1/20 0.60
HDAC7 Q8WUI4 1/20 0.60
HDAC10 Q969S8 1/20 0.60
HDAC11 Q96DB2 1/20 0.60
HDAC9 Q9UKV0 1/20 0.60
HDAC5 Q9UQL6 1/20 0.60
BCHE P06276 1/20 0.60
CYP3A4 P08684 1/20 0.60
NFKB1 P19838 1/20 0.60
NFKB2 Q00653 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2009524 1.00 F3 (0.72) F3THRBATMGSK3BHDAC3
SCHEMBL13067871 0.95 HDAC8 (0.69) F3THRBATMGSK3BHDAC3
SCHEMBL10399152 0.87 HDAC8 (0.63) F3THRBATMGSK3BHDAC3
SCHEMBL16410058 0.87 HDAC8 (0.63) F3THRBATMGSK3BHDAC3
SCHEMBL2744101 0.84 F3 (1.00) F3THRBATMGSK3BHDAC3
SCHEMBL2744098 0.84 F3 (1.00) F3THRBATMGSK3BHDAC3
SCHEMBL9073430 0.84 F3 (0.78) F3THRBATMGSK3BHDAC3
SCHEMBL9073433 0.84 F3 (0.78) F3THRBATMGSK3BHDAC3
SCHEMBL14331811 0.84 F3 (1.00) F3THRBATMGSK3BHDAC3
SCHEMBL1450230 0.83 F3 (0.52) F3HDAC3HDAC1HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102005220-B Compositions, optical data storage media and methods for using the optical data storage media GEN ELECTRIC 2015-06-03 CN claimed
CN-102005213-B Optical data storage media and methods for using the same GEN ELECTRIC 2015-05-13 CN claimed
CN-102005222-B Optical data storage method GEN ELECTRIC 2014-07-23 CN claimed
EP-1740152-B1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF SAIMDANG COSMETICS CO LTD (KR) 2012-12-26 EP claimed
CN-102592613-A Optical data storage media and methods for using the same GEN ELECTRIC 2012-07-18 CN claimed
US-20120147724-A1 OPTICAL DATA STORAGE MEDIA AND METHODS FOR USING THE SAME GENERAL ELECTRIC COMPANY (US) 2012-06-14 US claimed
JP-4828407-B2 2011-11-30 JP claimed
CN-102005222-A Compositions, optical data storage media and methods for using the optical data storage media GEN ELECTRIC 2011-04-06 CN claimed
CN-102005220-A Compositions, optical data storage media and methods for using the optical data storage media GEN ELECTRIC 2011-04-06 CN claimed
CN-102005213-A Optical data storage media and methods for using the same GEN ELECTRIC 2011-04-06 CN claimed
WO-2008062424-A2 SUBSTITUTED 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES AS CANNABINOID MODULATORS CADILA HEALTHCARE LIMITED (IN) 2008-05-29 WO claimed
US-20070249854-A1 Poly(Silsesquioxane) Spherical Particle Containing Ultraviolet Light-Absorbing Group and Manufacturing Method Thereof SAIMDANG COSMETICS CO., LTD. (KR) 2007-10-25 US claimed
EP-1594869-A2 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF Targacept, Inc. (US) 2005-11-16 EP claimed
WO-2004076449-A2 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF TARGACEPT, INC. (US) 2004-09-10 WO claimed
EP-0218622-B1 AMIDES OF PARA-METHOXYCINNAMIC AND UTILIZATION THEREOF AS SOLAR FILTERS Robert, Dominique (FR) 1991-07-10 EP claimed
CN-122095297-A Composition for forming cured film, alignment material, and phase difference material 2026-05-26 CN disclosed
WO-2025088969-A1 COMPOSITION FOR FORMING CURED FILM, CURED FILM, ALIGNMENT MATERIAL, AND RETARDATION MATERIAL 日産化学株式会社 2025-05-01 WO disclosed
US-4600777-A Method of preparing 1-alkyl-7-oxodecahydroquinolines, and cis(±) and tran(±)isomers so prepared ELI LILLY AND COMPANY (US) 1986-07-15 US disclosed
EP-0001997-B1 ELECTRON BEAM-CURABLE PHOTORESIST LACQUERS BAYER AG (DE) 1981-02-11 EP disclosed
EP-0001997-A1 Electron beam-curable photoresist lacquers BAYER AG (DE) 1979-05-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249854-A1 Poly(Silsesquioxane) Spherical Particle Containing Ultraviolet Light-Absorbing Group and Manufacturing Method Thereof STS, PARG, SBDS F3 1935/4885THRB 4676/4885ATM 1841/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.