Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11283022 | 1.00 | ALDH1A1 (0.37) | ALDH1A1LMNATSHRKMT2AHSD17B10 | |
| SCHEMBL10938530 | 0.69 | MAPT (0.33) | ALDH1A1KMT2AHPGD | |
| SCHEMBL7123770 | 0.69 | ALDH1A1 (0.37) | ALDH1A1LMNATSHRKMT2AHSD17B10 | |
| SCHEMBL1628615 | 0.69 | ALDH1A1 (0.37) | ALDH1A1LMNATSHRKMT2AHSD17B10 | |
| SCHEMBL10937868 | 0.68 | MAPT (0.33) | ALDH1A1KMT2AHPGD | |
| SCHEMBL10935590 | 0.68 | MAPT (0.33) | ALDH1A1KMT2AHPGD | |
| SCHEMBL4560700 | 0.67 | — | — | |
| SCHEMBL9632348 | 0.67 | PDE4A (0.38) | ALDH1A1LMNATSHRKMT2AHSD17B10 | |
| SCHEMBL5160089 | 0.67 | ALDH1A1 (0.35) | ALDH1A1LMNATSHRKMT2AHSD17B10 | |
| SCHEMBL4475890 | 0.67 | NLRP3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007403-B1 | 5,12-DIHYDROXY-1,2,3,4,6,11-HEXAHYDRO-2,6,11-TRIOXONAPHTHACENES AND THEIR SYNTHESIS | THE UNIVERSITY OF KANSAS (US) | 1982-11-24 | — | — | EP | claimed |
| US-4244880-A | Anthracycline synthesis | UNIVERSITY OF KANSAS ENDOWMENT ASSOCIATION (US) | 1981-01-13 | — | — | US | claimed |
| EP-0007403-A1 | 5,12-dihydroxy-1,2,3,4,6,11-hexahydro-2,6,11-trioxonaphthacenes and their synthesis | THE UNIVERSITY OF KANSAS (US) | 1980-02-06 | — | — | EP | claimed |
| WO-2015089349-A1 | INHIBITION OF ISOPRENOID BIOSYNTHETIC PATHWAYS TO TREAT NEUROINFLAMMATORY DISORDERS | TABACZYNSKI DAVID A (US) | 2015-06-18 | — | — | WO | disclosed |
| CN-101885674-B | Preparation method of 5,8-dimethoxy-2-tetralin ketone | GANSU HAOTIAN CHEMEXPRESS CO LTD | 2015-03-11 | — | — | CN | disclosed |
| CN-101885674-A | Preparation method of 5,8-dimethoxy-2-tetralin ketone | GANSU HAOTIAN CHEMEXPRESS CO LTD | 2010-11-17 | — | — | CN | disclosed |
| US-4975461-A | Enzymes/oxidoreductases/inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0136893-B1 | Benzo[a]phenothiazines and hydro-derivatives and pharmaceutical compositions containing them | MERCK FROSST CANADA INC. (CA) | 1989-08-16 | — | — | EP | disclosed |
| EP-0007403-B1 | 5,12-DIHYDROXY-1,2,3,4,6,11-HEXAHYDRO-2,6,11-TRIOXONAPHTHACENES AND THEIR SYNTHESIS | THE UNIVERSITY OF KANSAS (US) | 1982-11-24 | — | — | EP | disclosed |
| EP-0043435-A1 | Intermediate products occurring in anthracycline synthesis | THE UNIVERSITY OF KANSAS (US) | 1982-01-13 | — | — | EP | disclosed |
| US-4267373-A | HYDROXY- OR -OXY-SUBSTITUTED-6-ALKYL- OR DIALKYLAMINO-7-HYDROXY DERIVATIVES | E. R. SQUIBB & SONS, INC. (US) | 1981-05-12 | — | — | US | disclosed |
| US-4244880-A | Anthracycline synthesis | UNIVERSITY OF KANSAS ENDOWMENT ASSOCIATION (US) | 1981-01-13 | — | — | US | disclosed |
| EP-0007404-A1 | Synthesis of 2-hydroxy-2-acetyl-1,2,3,4-tetrahydronaphthalene compounds | THE UNIVERSITY OF KANSAS (US) | 1980-02-06 | — | — | EP | disclosed |
| EP-0007403-A1 | 5,12-dihydroxy-1,2,3,4,6,11-hexahydro-2,6,11-trioxonaphthacenes and their synthesis | THE UNIVERSITY OF KANSAS (US) | 1980-02-06 | — | — | EP | disclosed |
| US-4076843-A | 5,6,7,8-Tetrahydronaphthalene hypotensive agents | E. R. SQUIBB & SONS, INC. (US) | 1978-02-28 | — | — | US | disclosed |