Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401022 | 0.86 | HRH2 (0.53) | SMN1; SMN2ALDH1A1HRH2 | |
| SCHEMBL10504087 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2TDP1ALDH1A1HRH2PRMT6 | |
| SCHEMBL9574835 | 0.85 | HRH2 (0.55) | SMN1; SMN2ALDH1A1HRH2 | |
| SCHEMBL11268821 | 0.84 | HRH2 (0.54) | SMN1; SMN2HRH2 | |
| SCHEMBL10401250 | 0.84 | HRH2 (0.54) | SMN1; SMN2HRH2 | |
| SCHEMBL10744580 | 0.83 | HRH2 (0.53) | SMN1; SMN2ALDH1A1HRH2 | |
| SCHEMBL11263724 | 0.83 | HRH2 (0.53) | SMN1; SMN2HRH2 | |
| SCHEMBL10667188 | 0.83 | HRH2 (0.53) | HRH2 | |
| SCHEMBL11271145 | 0.82 | HRH2 (0.52) | SMN1; SMN2ALDH1A1HRH2 | |
| SCHEMBL11263720 | 0.82 | HRH2 (0.52) | SMN1; SMN2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4952589-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-08-28 | — | — | US | disclosed |
| EP-0181163-B1 | HETEROCYCLIC PHENOXY DERIVATIVES HAVING AN ANTIHISTAMINE H2 ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |
| US-4681883-A | Histamine H2 -antagonist oxazole and thiazole derivatives and compositions therefor | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-07-21 | — | — | US | disclosed |
| EP-0181163-A2 | Heterocyclic phenoxy derivatives having an antihistamine H2 activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-05-14 | — | — | EP | disclosed |