Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10744580 | 0.99 | HRH2 (0.53) | HRH2HRH3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11268821 | 0.96 | HRH2 (0.54) | HRH2HRH3SMN1; SMN2TP53CYP1A2 | |
| SCHEMBL10401250 | 0.96 | HRH2 (0.54) | HRH2HRH3SMN1; SMN2TP53CYP1A2 | |
| SCHEMBL10667188 | 0.95 | HRH2 (0.53) | HRH2HRH3 | |
| SCHEMBL11263724 | 0.95 | HRH2 (0.53) | HRH2HRH3SMN1; SMN2TP53CYP1A2 | |
| SCHEMBL11271145 | 0.95 | HRH2 (0.52) | HRH2HRH3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11263720 | 0.94 | HRH2 (0.52) | HRH2HRH3SMN1; SMN2TP53CYP1A2 | |
| SCHEMBL10401022 | 0.93 | HRH2 (0.53) | HRH2HRH3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11100387 | 0.91 | HRH2 (0.50) | HRH2HRH3 | |
| SCHEMBL10663929 | 0.86 | HRH3 (0.59) | HRH3SMN1; SMN2KDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5212187-A | Antihistamines | ZYMA SA (CH) | 1993-05-18 | — | — | US | disclosed |
| EP-0526395-A1 | Arylalkylamine derivatives, process for their preparation and pharmaceutical compositions containing them | Zyma SA (CH) | 1993-02-03 | — | — | EP | disclosed |
| US-4952589-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-08-28 | — | — | US | disclosed |
| EP-0181163-B1 | HETEROCYCLIC PHENOXY DERIVATIVES HAVING AN ANTIHISTAMINE H2 ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |
| US-4808589-A | Pyrimidone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-28 | — | — | US | disclosed |
| EP-0134096-B1 | AMINOPYRIMIDINONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-01 | — | — | EP | disclosed |
| US-4767769-A | HISTAMINE-H2 ANTAGONISTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | disclosed |
| US-4764612-A | SELECTIVE HISTAMINE H2-ANTAGONIST | GLAXO GROUP LIMITED (GB) | 1988-08-16 | — | — | US | disclosed |
| US-4681883-A | Histamine H2 -antagonist oxazole and thiazole derivatives and compositions therefor | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-07-21 | — | — | US | disclosed |
| EP-0086647-B1 | PYRIMIDONE COMPOUNDS, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-09-17 | — | — | EP | disclosed |
| EP-0173377-A2 | Pyrimidone compounds, their preparation and pharmaceutical compositions containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1986-03-05 | — | — | EP | disclosed |
| EP-0172631-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1986-02-26 | — | — | EP | disclosed |
| US-4536508-A | ANTIALLERGENS AND ANTIINFLAMMATORY AGENTS | GLAXO GROUP LIMITED (GB) | 1985-08-20 | — | — | US | disclosed |
| EP-0134096-A2 | Aminopyrimidinone derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-03-13 | — | — | EP | disclosed |
| EP-0016565-B1 | 1,2,4-TRIAZOLE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1984-05-23 | — | — | EP | disclosed |
| US-4442110-A | ANTISECRETORY, ANTIALLERGEN, ANTIINFLAMMATORY, ANTIULCER | GLAXO GROUP LIMITED (GB) | 1984-04-10 | — | — | US | disclosed |
| EP-0087274-A2 | Pyrimidone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-08-31 | — | — | EP | disclosed |
| EP-0086647-A2 | Pyrimidone compounds, their preparation, and pharmaceutical compositions containing them | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1983-08-24 | — | — | EP | disclosed |
| EP-0050407-A1 | 3,5-Disubstituted-1,2,4-triazole compounds, processes for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1982-04-28 | — | — | EP | disclosed |
| US-4318913-A | 1,2,4-Triazole-3,5-diamine derivatives | GLAXO GROUP LIMITED (GB) | 1982-03-09 | — | — | US | disclosed |