Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 5/20 | 0.33 |
| ▸ | PPARD | Q03181 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401481 | 0.92 | MAPT (0.37) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10405373 | 0.87 | MTNR1A (0.37) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10401465 | 0.86 | CA12 (0.36) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10401766 | 0.83 | PPARD (0.33) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10405477 | 0.72 | MEN1 (0.36) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10405675 | 0.72 | MEN1 (0.37) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10404356 | 0.68 | MAOB (0.39) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10404833 | 0.68 | KAT6A (0.38) | MEN1KMT2ASMN1; SMN2KDM4EPPARG | |
| SCHEMBL9868005 | 0.68 | MAPT (0.39) | MAPTMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL9868008 | 0.68 | MAPT (0.39) | MAPTMEN1LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4978679-A | 6- and/or 7-substituted-1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis | MERCK & CO., INC. (US) | 1990-12-18 | — | — | US | disclosed |