Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.57 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401659 | 1.00 | GRM4 (0.57) | GRM4CYSLTR2CYSLTR1MAPTRAB9A | |
| SCHEMBL28435833 | 0.82 | RAB9A (0.65) | CYSLTR2CYSLTR1MAPTRAB9AKDM4E | |
| SCHEMBL28435835 | 0.82 | RAB9A (0.65) | CYSLTR2CYSLTR1MAPTRAB9AKDM4E | |
| SCHEMBL1246543 | 0.78 | KDM4E (0.57) | CYSLTR2CYSLTR1MAPTRAB9AKDM4E | |
| SCHEMBL1244748 | 0.77 | KDM4E (0.56) | CYSLTR2CYSLTR1MAPTRAB9AKDM4E | |
| SCHEMBL1246644 | 0.76 | MAPT (0.54) | CYSLTR2CYSLTR1MAPTRAB9AKDM4E | |
| SCHEMBL10444695 | 0.76 | NPC1 (0.55) | RAB9AKDM4ENPC1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL9779738 | 0.74 | HPGD (0.53) | GRM4MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL20921524 | 0.74 | RAB9A (0.68) | CYSLTR2CYSLTR1MAPTRAB9AKDM4E | |
| SCHEMBL6483597 | 0.74 | RAB9A (0.68) | CYSLTR2CYSLTR1MAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4962203-A | ANTIASTHMATIC, ANTIALLERGENIC, ANTIINFLAMMATORY AND CYTOPROTECTIVE AGENTS | MERCK FROST CANADA, INC. (CA) | 1990-10-09 | — | — | US | disclosed |
| EP-0206751-A2 | 2-Substituted quinolines, their preparation and use | MERCK FROSST CANADA INC. (CA) | 1986-12-30 | — | — | EP | disclosed |