SCHEMBL10401702

SCHEMBL10401702

O=C(NC1CN(C(=O)c2ccccc2)C1)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
EPHX1 P07099 1/20 0.55
CHRNB2 P17787 2/20 0.54
CHRNB4 P30926 2/20 0.54
CHRNA3 P32297 2/20 0.54
CHRNA7 P36544 2/20 0.54
CHRNA4 P43681 2/20 0.54
CTSL P07711 1/20 0.52
CTSB P07858 1/20 0.52
CTSK P43235 1/20 0.52
POLB P06746 1/20 0.52
CHRM4 P08173 1/20 0.52
F2R P25116 1/20 0.52
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
PLA2G1B P04054 1/20 0.50
ATG4B Q9Y4P1 1/20 0.50
NPSR1 Q6W5P4 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL144377 0.88 CTSL (0.54) MEN1KMT2ACTSLCTSBCTSK
SCHEMBL3316788 0.85 MEN1 (0.57) MEN1KMT2AEPHX1CTSLCTSB
SCHEMBL3316785 0.85 MEN1 (0.57) MEN1KMT2AEPHX1CTSLCTSB
SCHEMBL121355 0.83 SMN1; SMN2 (0.57) MEN1KMT2ACTSLCTSBCTSK
SCHEMBL4345747 0.81 CARM1 (0.56) MEN1KMT2ACTSLCTSBCTSK
SCHEMBL16565830 0.81 CHRNB2 (0.56) MEN1KMT2AEPHX1CHRNB2CHRNB4
SCHEMBL16564154 0.80 MEN1 (0.54) MEN1KMT2ACHRNB2CHRNB4CHRNA3
SCHEMBL16564487 0.80 CHRM1 (0.48) MEN1KMT2AEPHX1POLBHPGD
SCHEMBL994466 0.79 CTSL (0.63) MEN1KMT2AEPHX1CTSLCTSB
SCHEMBL3319118 0.78 KMT2A (0.57) MEN1KMT2APOLBNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4822895-A 3-aminoazetidine, its salts and intermediates of synthesis SOCIETE ANONYME - SANOFI (FR) 1989-04-18 US claimed
US-4943641-A 3-aminoazetidine, its salts, process for their preparation and intermediates of synthesis SANOFI (FR) 1990-07-24 US disclosed
EP-0155870-B1 3-AMINOAZETIDINE, ITS SALTS, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES SANOFI (FR) 1989-04-26 EP disclosed
US-4822895-A 3-aminoazetidine, its salts and intermediates of synthesis SOCIETE ANONYME - SANOFI (FR) 1989-04-18 US disclosed
EP-0155870-A1 3-Aminoazetidine, its salts, process for their preparation and intermediates SANOFI (FR) 1985-09-25 EP disclosed