SCHEMBL10403133

SCHEMBL10403133

[O]C(=O)NN1CCNCC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GNAI3 P08754 2/20 0.46
GNAO1 P09471 2/20 0.46
GNAI1 P63096 2/20 0.46
CA2 P00918 3/20 0.39
CA12 O43570 2/20 0.39
CA9 Q16790 2/20 0.39
CA1 P00915 1/20 0.39
CHKA P35790 1/20 0.38
CHRNB2 P17787 1/20 0.37
CHRNA3 P32297 1/20 0.37
CHRNA4 P43681 1/20 0.37
CHRNB3 Q05901 1/20 0.37
CHRNA6 Q15825 1/20 0.37
CHRM5 P08912 2/20 0.34
CHRM3 P20309 2/20 0.34
SIGMAR1 Q99720 3/20 0.32
POLB P06746 1/20 0.32
EPHX2 P34913 1/20 0.32
HSD11B1 P28845 1/20 0.31
EPHX1 P07099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3267951 0.80 GNAI3 (0.46) GNAI3GNAO1GNAI1CA2CA12
SCHEMBL4823917 0.78 GNAI3 (0.44) GNAI3GNAO1GNAI1CA2CA12
SCHEMBL1459326 0.78 GNAI3 (0.44) GNAI3GNAO1GNAI1CA2CA12
SCHEMBL1394575 0.78 GNAI3 (0.49) GNAI3GNAO1GNAI1CA2CA12
SCHEMBL8897925 0.78 GNAI3 (0.44) GNAI3GNAO1GNAI1CA2CA12
SCHEMBL29108006 0.76 GNAI3 (0.47) GNAI3GNAO1GNAI1CA2CA12
Hydrochloric Acid SCHEMBL27503795 0.76 GNAI3 (0.47) GNAI3GNAO1GNAI1CA2CA12
Hydrochloric Acid SCHEMBL3258527 0.76 GNAI3 (0.47) GNAI3GNAO1GNAI1CA2CA12
SCHEMBL5495808 0.76
SCHEMBL11443167 0.75 GNAI3 (0.42) GNAI3GNAO1GNAI1CA2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4914206-A ANTIBIOTICS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-04-03 US disclosed
EP-0226896-A2 Lankacidin derivatives and production thereof Takeda Chemical Industries, Ltd. (JP) 1987-07-01 EP disclosed