Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25834322 | 0.86 | MAPT (0.53) | TOP1MAPTKDM4EMEN1PKM | |
| SCHEMBL196440 | 0.74 | MGAM (0.55) | TOP1MAPTKDM4EMAPK1TDP1 | |
| SCHEMBL29241865 | 0.72 | MAOA (0.64) | MAPTKDM4EMEN1PKMMAPK1 | |
| SCHEMBL31189139 | 0.72 | MAOA (0.64) | MAPTKDM4EMEN1PKMMAPK1 | |
| SCHEMBL5455002 | 0.72 | MAPK1 (0.57) | MAPTKDM4EMEN1PKMMAPK1 | |
| SCHEMBL11332343 | 0.72 | POLM (0.43) | MAPTMEN1KMT2ABACE1LMNA | |
| SCHEMBL21796070 | 0.71 | PTPRC (0.47) | MAPTKDM4EMEN1PKMMAPK1 | |
| SCHEMBL16674078 | 0.70 | CA1 (0.55) | MAPTKDM4EMAPK1TDP1ALDH1A1 | |
| SCHEMBL28580646 | 0.70 | MAOA (0.52) | TOP1MAPTKDM4EMEN1PKM | |
| SCHEMBL11352814 | 0.70 | MAPT (0.50) | MAPTKDM4EMEN1PKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933489-A | Process for the manufacture of 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene | WARNER-LAMBERT COMPANY (US) | 1990-06-12 | — | — | US | claimed |
| EP-0221474-B1 | PROCESS FOR THE MANUFACTURE OF 6-CHLORO-1,4-DIACETOXY-2,3-DIMETHOXYNAPHTHALENE | WARNER-LAMBERT COMPANY (US) | 1990-01-17 | — | — | EP | claimed |
| EP-0221474-A1 | Process for the manufacture of 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | claimed |
| US-4933489-A | Process for the manufacture of 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene | WARNER-LAMBERT COMPANY (US) | 1990-06-12 | — | — | US | disclosed |
| US-4933489-A | Process for the manufacture of 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene | WARNER-LAMBERT COMPANY (US) | 1990-06-12 | — | — | US | disclosed |
| EP-0221474-B1 | PROCESS FOR THE MANUFACTURE OF 6-CHLORO-1,4-DIACETOXY-2,3-DIMETHOXYNAPHTHALENE | WARNER-LAMBERT COMPANY (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0221474-A1 | Process for the manufacture of 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |